Figure 2 - uploaded by David Lee Hamilton
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Schematic representation of the activation of mTORC1 by resistance exercise. Note that the activation of mTORC1 by integrin-linked kinase-induced PKB phophosylation and/or MAP4K3 are at this point hypothetical. However, the role of the other factors including phosphatidic acid and Vps34 have been seen experimentally.
Source publication
Skeletal muscle has a tremendous capacity to adapt to the functional and metabolic loads placed upon it. This plasticity is most apparent in the physique of the strength athlete who has utilized the principles of progressive resistance exercise to improve their skeletal muscle mass and function. The most striking adaptation to progressive resistanc...
Context in source publication
Context 1
... these data suggest that mTORC1 regulates work-induced muscle growth through S6K1 and 4EBP/eIF4E. These proteins selectively increase the translation of important growth response genes such as cyclin D1 [173], eIF2B [179], and ribosomal proteins [144] resulting in an overall increase in translation and ribosomal biogenesis (Figure 2). Repeating the exercise stimulus at a sufficient frequency would result in greater protein accretion and muscle hypertrophy. ...
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