Figure 2 - uploaded by Maria Riaz
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Schematic representation of activated platelets interaction with cancer cells as well as initiate EMT and both of them induce cancer metastasis.
Source publication
Platelets are small anucleated cell fragments that ensure the stopping of bleeding. In blood metastasis of cancer, Platelets are essential. One of the most important aspects of cancer metastasis is the interaction between platelets and circulating tumor cells. Platelets are involved in cancer spread and constitute a hazardous collation with the can...
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Citations
... The first action of the antiangiogenesis medication is to inhibit the intermediaries involved in blood vessel formation. The release of the anti-cancer medication subsequently leads to the effective elimination of cancer cells [66] . A nanoscale, an effective vehicle for the anticancer medication to reach the neoplastic location, enables all of that. ...
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Nanotechnology has far-reaching implications and applications in multiple fields. The biomedical and health sectors can use nanotechnology concepts for medication delivery and treatment. Under controlled conditions, it can target and initiate administering drugs and several other therapeutic agents. Since cancer is the largest cause of death worldwide, prompt diagnosis and effective anticancer treatments are crucial. In this particular context, nanotechnology reduces side effects and directs drug delivery to specifically target cancer cells, providing unique benefits for cancer therapy. In the present thorough review, the most noteworthy new findings for 2010–2023 were compiled, which address the development and use of nanosystems for cancer treatment. Nanoparticles allow precise and controlled release of therapeutic substances at specific action locations, enabling targeted medication delivery. Size, shape, surface, charge, and loading methods impact its efficiency. Researchers have made advancements in encapsulating drugs into nanoliposomes and nanoemulsions, including paclitaxel and fisetin, and are currently testing their suitability in ongoing clinical trials. The purpose of this review is to serve as a continuous path toward recognizing the extraordinary potential of various nanoparticles in cancer therapies.
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Metastasis refers to disseminating cancerous tumors from their primary site to distant locations inside the body. Cancer cells must go through a sequence of events called the “metastatic cascade” to develop metastases. Each stage necessitates a unique functional alteration. Cancer stem cells (CSCs) play a crucial role in tumor metastasis, but understanding their dynamic behavior and regulating mechanisms remains incomplete. This review explores the influence of liver CSCs on the biological processes that drive the spread and growth of cancer cells, as described by the “metastatic cascade” concept. Liver CSCs can spread to other organs by undergoing epithelial-mesenchymal transition (EMT). This alteration in the microenvironment facilitates cellular dissemination, immune surveillance evasion, dormancy induction, and subsequent reactivation. To effectively prevent and treat advanced hepatocellular carcinoma (HCC) metastases, it is crucial to understand the heterogeneity and features of liver CSCs involved in these processes.
