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Sampling regions (a) and representative images of Esr2 puncta in the mPFC (b), motor cortex (c), and dorsal striatum (d). Images show Esr2 puncta in pre-pubertal, adolescent females. Scalebar = 20 µm.

Sampling regions (a) and representative images of Esr2 puncta in the mPFC (b), motor cortex (c), and dorsal striatum (d). Images show Esr2 puncta in pre-pubertal, adolescent females. Scalebar = 20 µm.

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In female rats, pubertal onset is associated with maturation of the medial prefrontal cortex (mPFC) and mPFC-mediated behaviors. These behavioral and anatomical changes are likely due to effects of estrogen at the nuclear estrogen receptor beta (ERβ), which is expressed at higher levels than the estrogen receptor alpha (ERα) isoform in the adult mP...

Contexts in source publication

Context 1
... were acquired from layer II/III of the mPFC, layers II/III and V/VI of the motor cortex, and the dorsolateral and dorsomedial striatum. Regions of interest were identified using the DAPI stain, and 8 separate images (4 per hemisphere) were acquired for each subject within each subregion analyzed (Figure 1). Images were obtained by taking z-stacks of 30 separate images across 20.3 µm of tissue at 8 unique sites within each region. ...
Context 2
... were acquired from layer II/III of the mPFC, layers II/III and V/VI of the motor cortex, and the dorsolateral and dorsomedial striatum. Regions of interest were identified using the DAPI stain, and 8 separate images (4 per hemisphere) were acquired for each subject within each subregion analyzed (Figure 1). Images were obtained by taking z-stacks of 30 separate images across 20.3 µm of tissue at 8 unique sites within each region. ...