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Figure 2 - A hyperthermic seizure unleashes a surge of spreading depolarizations in Scn1a-deficient mice

Figure 2. SD generation during hyperthermic seizures induced with a heating lamp in Scn1a +/RX mice. (A and B) Representative EEG showing seizure and SD. Top: DC; middle: high pass (>1 Hz); bottom: power spectrum of EEG (anterior electrode). (C) Postictal SD was less common in WT mice: 77% (10/13) of Scn1a +/RX mice developed SD following seizure, while 27% (3/11) of WT mice did so. (D) Consistent with previous studies, Scn1a +/RX mice showed a lowered thermal threshold for seizure. WT: n = 11; Scn1a +/RX : n = 13; P = 0.007, Mann-Whitney U test. **P < 0.01.
SD generation during hyperthermic seizures induced with a heating lamp in Scn1a +/RX mice. (A and B) Representative EEG showing seizure and SD. Top: DC; middle: high pass (>1 Hz); bottom: power spectrum of EEG (anterior electrode). (C) Postictal SD was less common in WT mice: 77% (10/13) of Scn1a +/RX mice developed SD following seizure, while 27% (3/11) of WT mice did so. (D) Consistent with previous studies, Scn1a +/RX mice showed a lowered thermal threshold for seizure. WT: n = 11; Scn1a +/RX : n = 13; P = 0.007, Mann-Whitney U test. **P < 0.01.
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