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LncRNAs (Long noncoding RNAs) are novel group of ncRNAs and has been discovered to be pervasively transcripted in the genome, characterized as endogenous cellular RNAs consist of more than 200 nucleotides. They are ordered in view of function, transcript length, relation with protein-coding genes and other functional DNA elements, and subcellular l...
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In recent biomedical studies, omics profiling has been extensively conducted on various types of mental disorders. In most of the existing analyses, a single type of mental disorder and a single type of omics measurement are analyzed. In the study of other complex diseases, integrative analysis, both vertical and horizontal integration, has been co...
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... However, it is already known that the transcriptomics approach could eventually detect the activities of the genes that are beyond the coverage of the genomics and proteomics-based technology (Dong and Chen 2013). In this regard, transcriptomics-based markers are already widely utilized for molecular medicine and agriculture research (Parikesit et al. 2017;Anurogo et al. 2019). Moreover, aquatic-based biomarkers have been developed for fish breeding as well (Collí-Dulá et al. 2016). ...
Tilapia (Oreochromis niloticus) is an important fisheries commodity. Scientific efforts have been done to increase its quality. One of them is staging a premium diet such as a fat-enriched diet. The transcriptomics approach is able to provide the signatures of the diet outcomes by observing the micro(mi)RNA signature in transcriptional regulation. Hence, it was found that the availability of mir-122 is essential in the regulation of a high-fat diet in tilapia. However, this transcriptomics signature is lacking structural annotations and the complete interaction annotations with its silencing(si)RNA. RNAcentral website was navigated for the latest annotation of mir-122 from tilapia and other species as a comparison. MEGA X was employed to comprehend the miRNA evolutionary repertoire. The RNA secondary structure prediction tools from the Vienna RNA package and the RNA tertiary structure prediction tools from simRNA and modeRNA are secured with default parameters. The HNADOCK tools were leveraged to observe the interaction between mir-122 and its siRNA. The post-processing was conducted with the Chimera visualization tool. The secondary and tertiary structure of the mir-122 and its siRNA could be elucidated, docked, and visualized. In this end, further effort to develop a comprehensive molecular breeding tool could be secured with the structural annotation information.
... The high-dimensional assays and advanced genetic, supported by bioinformatics technologies have experienced to a contemporary era of genetic arrangement of vaccines and have contributed real solutions to the impediments presently hindering advancement in this scope (Table 2) [47]. With the latest developments in technology-based multidisciplinary omics, personalized medicine-based vaccines will be better developed, of course still paying attention to safety, efficacy, and (bio) ethical aspects [48] [49]. ...
