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Expyriment is an open-source and platform-independent lightweight Python library for designing and conducting timing-critical behavioral and neuroimaging experiments. The major goal is to provide a well-structured Python library for script-based experiment development, with a high priority being the readability of the resulting program code. Expyri...
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Identifying strategies for researchers has been a problem investigated from different perspectives, such as choosing research topics or the effect of partner selection. Its importance lies in the effect these choices have in the long term and the importance of taking them into account at the beginning of the scientific career. This study aims to id...
Citations
... Self-report questionnaires are used to assess perceived stress (e.g., subjective fear ratings). These are acquired via Expyriment [53], the software we use to present task stimuli, along with assessments of behavioural responses (e.g., reaction time, response accuracy) recorded during stress regulation tasks. Physiological response assessments of autonomic nervous system measures (e.g., skin conductance, heart rate, and pupil size) are used to measure affective responses to stressors using BrainVision Recorder (Brain Products; Gliching, Germany) and Eyelink-1000 Plus eye-tracker (SR Research, Ottawa, Canada). ...
Background
Stress-related disorders are a growing public health concern. While stress is a natural and adaptive process, chronic exposure to stressors can lead to dysregulation and take a cumulative toll on physical and mental well-being. One approach to coping with stress and building resilience is through Mindfulness-Based Stress Reduction (MBSR). By understanding the neural mechanisms of MBSR, we can gain insight into how it reduces stress and what drives individual differences in treatment outcomes. This study aims to establish the clinical effects of MBSR on stress regulation in a population that is susceptible to develop stress-related disorders (i.e., university students with mild to high self-reported stress), to assess the role of large-scale brain networks in stress regulation changes induced by MBSR, and to identify who may benefit most from MBSR.
Methods
This study is a longitudinal two-arm randomised, wait-list controlled trial to investigate the effects of MBSR on a preselected, Dutch university student population with elevated stress levels. Clinical symptoms are measured at baseline, post-treatment, and three months after training. Our primary clinical symptom is perceived stress, with additional measures of depressive and anxiety symptoms, alcohol use, stress resilience, positive mental health, and stress reactivity in daily life. We investigate the effects of MBSR on stress regulation in terms of behaviour, self-report measures, physiology, and brain activity. Repetitive negative thinking, cognitive reactivity, emotional allowance, mindfulness skills, and self-compassion will be tested as potential mediating factors for the clinical effects of MBSR. Childhood trauma, personality traits and baseline brain activity patterns will be tested as potential moderators of the clinical outcomes.
Discussion
This study aims to provide valuable insights into the effectiveness of MBSR in reducing stress-related symptoms in a susceptible student population and crucially, to investigate its effects on stress regulation, and to identify who may benefit most from the intervention.
Trial registration
Registered on September 15, 2022, at clinicaltrials.gov, NCT05541263.
... Two computers were used to conduct the experiment: the first presented stimuli, the second recorded the data. The first computer sent an initial trigger through the parallel port and a terminal trigger to the second computer, then the force signal was recorded using Expyriment software [67] at a sampling rate of 1 kHz through an analog-to-digital converter card. Forces were measured in millinewtons (mN). ...
People respond faster to smaller numbers in their left space and to larger numbers in their right space. Here we argue that movements in space contribute to the formation of spatial-numerical associations (SNAs). We studied the impact of continuous isometric forces along the horizontal or vertical cardinal axes on SNAs while participants performed random number production and arithmetic verification tasks. Our results suggest that such isometric directional force do not suffice to induce SNAs.
... The formula used to calculate interoceptive accuracy was also used to calculate the time estimation task accuracy. The heartbeat counting task and the time estimation task were designed using the Expyriment computer software 33 www.nature.com/scientificreports/ The graphesthesia task paradigm. ...
Information can be perceived from a multiplicity of spatial perspectives, which is central to effectively understanding and interacting with our environment and other people. Interoception, the sense of the physiological state of our body, is also a fundamental component contributing to our perception. However, whether the perception of our inner body signals influences our ability to adopt and flexibly change between different spatial perspectives remains poorly understood. To investigate this, 90 participants completed tasks assessing multiple dimensions of interoception (interoceptive sensibility, cardiac interoceptive accuracy and awareness) and the Graphesthesia task to assess tactile spatial perspective-taking and its flexibility. The results revealed that higher cardiac interoceptive awareness is associated with greater consistency in adopting a perspective decentred from the self. Second, higher cardiac interoceptive accuracy was associated with slower and less accurate performance in switching from a decentred to an egocentred perspective. These results show that interoceptive abilities facilitate decentred spatial perspective-taking, likely reflecting stronger perceived boundaries between internal states and the external world.
... To achieve precisely 3.4 s of stimulation, the NEMOS® device was 102 controlled using two linear actuators which pressed the ON/OFF buttons. These 'push' commands 103 were sent at pre-programmed times via an Arduino mini, and were embedded within the task script, 104 which was programmed using the Expyriment Python package [33]. Two checks were implemented 105 to ensure that only trials with good connection between the electrodes and the skin were included. ...
Background: Transcutaneous auricular vagus nerve stimulation (taVNS) is a promising brain stimulation method for the treatment of pharmaco-resistant epilepsy and depression. Its clinical efficacy is thought to depend on taVNS-induced activation of the locus coeruleus. However, unlike for invasive VNS, there is little evidence for an effect of taVNS on noradrenergic activity.
Objective: We attempted to replicate recently published findings by Sharon et al. (2021), showing that short bursts of taVNS transiently increased pupil size and decreased EEG alpha power, two correlates of central noradrenergic activity.
Methods: Following the original study, we used a single-blind, sham-controlled, randomized cross-over design. We applied short-term (3.4 s) taVNS in healthy human volunteers (n=29), while collecting resting-state pupil-size and EEG data. To analyze the data, we used scripts provided by Sharon and colleagues.
Results: Consistent with Sharon et al. (2021), pupil dilation was significantly larger during taVNS than during sham stimulation (p = .009; Bayes factor supporting the difference = 7.45). However, we failed to replicate the effect of taVNS on EEG alpha power (p = .37); the data were four times more likely under the null hypothesis (BF10 = 0.28).
Conclusion: Our findings support the effectiveness of short-term taVNS in inducing transient pupil dilation, a correlate of phasic noradrenergic activity. However, we failed to replicate the recent finding by Sharon et al. (2021) that taVNS attenuates EEG alpha activity. Overall, this study highlights the need for continued research on the neural mechanisms underlying taVNS efficacy and its potential as a treatment option for pharmaco-resistant conditions. It also highlights the need for direct replications of influential taVNS studies.
... Experimental setup. Experiment 1 was implemented in Python with the expyriment package (Krause & Lindemann, 2014) and run on an ASUS UX31 laptop. The program presented the audio stimuli binaurally at a comfortable hearing level via headphones (Sennheiser HD 250 linear) and recorded the participants' written responses. ...
Humans are expert at processing speech but how this feat is accomplished remains a major question in cognitive neuroscience. Capitalizing on the concept of channel capacity, we developed a unified measurement framework to investigate the respective influence of seven acoustic and linguistic features on speech comprehension, encompassing acoustic, sub-lexical, lexical and supra-lexical levels of description. We show that comprehension is independently impacted by all these features, but at varying degrees and with a clear dominance of the syllabic rate. Comparing comprehension of French words and sentences further reveals that when supra-lexical contextual information is present, the impact of all other features is dramatically reduced. Finally, we estimated the channel capacity associated with each linguistic feature and compared them with their generic distribution in natural speech. Our data reveal that while acoustic modulation, syllabic and phonemic rates unfold respectively at 5, 5, and 12 Hz in natural speech, they are associated with independent processing bottlenecks whose channel capacity are of 15, 15 and 35 Hz, respectively, as suggested by neurophysiological theories. They moreover point towards supra-lexical contextual information as the feature limiting the flow of natural speech. Overall, this study reveals how multilevel linguistic features constrain speech comprehension.
... To reduce ocular artefacts, participants were instructed to fixate on a cross on the monitor while listening to the stimuli. The stimulus presentation and response time recording was controlled using the opensource Expyriment software v0.9.0 (Krause & Lindemann, 2014). ...
The norepinephrine locus coeruleus system (LC NE) represents a promising treatment target in patients with insomnia disorder (ID) due to its well understood links to arousal and sleep regulation. However, consistent markers of LC NE activity are lacking. This study measured three potential indirect markers of LC NE activity – REM sleep, P3 amplitude during an auditory oddball paradigm (as a marker of phasic LC activation), and baseline pupil diameter (as a marker of tonic LC activation). The parameters were then combined in a statistical model and tested to compare LC NE activity between 20 subjects with insomnia disorder (13 female; age 44.2 ± 15.1 year) and 20 healthy, good sleeping controls (GSC; 11 female; age 45.4 ± 11.6 year). No group differences regarding the primary outcome parameters were detected. Specifically, insomnia disorder did not display the hypothesised changes in markers of LC NE function. While increased LC NE function remains an interesting speculative pathway for hyperarousal in insomnia disorder, the investigated markers do not appear closely related to each other and fail to discriminate between insomnia disorder and good sleeping controls in these samples.
... The experimenter was seated at another desk and registered participants' verbal responses by mouse click. We used OpenSesame (Mathôt et al., 2012) for stimuli presentation and collected force data at a separate PC using custommade software based on the Python-library Expyriment software (Krause & Lindemann, 2014). All instructions were given in English. ...
In numerical processing, the functional role of Spatial-Numerical Associations (SNAs, such as the association of smaller numbers with left space and larger numbers with right space, the Mental Number Line hypothesis) is debated. Most studies demonstrate SNAs with lateralized responses, and there is little evidence that SNAs appear when no response is required. We recorded passive holding grip forces in no-go trials during number processing. In Experiment 1, participants performed a surface numerical decision task (“Is it a number or a letter?”). In Experiment 2, we used a deeper semantic task (“Is this number larger or smaller than five?”). Despite instruction to keep their grip force constant, participants' spontaneous grip force changed in both experiments: Smaller numbers led to larger force increase in the left than in the right hand in the numerical decision task (500–700 ms after stimulus onset). In the semantic task, smaller numbers again led to larger force increase in the left hand, and larger numbers increased the right-hand holding force. This effect appeared earlier (180 ms) and lasted longer (until 580 ms after stimulus onset). This is the first demonstration of SNAs with passive holding force. Our result suggests that (1) explicit motor response is not a prerequisite for SNAs to appear, and (2) the timing and strength of SNAs are task-dependent. (216 words).
... The experimenter was seated at another desk and registered participants' verbal responses by mouse click. We used OpenSesame (Mathôt et al., 2012) for stimuli presentation and collected force data at a separate PC using custommade software based on the Python-library Expyriment software (Krause & Lindemann, 2014). All instructions were given in English. ...
In numerical processing, the functional role of Spatial-Numerical Associations (SNAs, such as the association of smaller numbers with left space and larger numbers with right space, the Mental Number Line hypothesis) is debated. Most studies demonstrate SNAs with lateralized responses, and there is little evidence that SNAs appear when no response is required. We recorded passive holding grip forces in no-go trials during number processing. In Experiment 1, participants performed a surface numerical decision task (“Is it a number or a letter?”). In Experiment 2, we used a deeper semantic task (“Is this number larger or smaller than five?”). Despite instruction to keep their grip force constant, participants' spontaneous grip force changed in both experiments: Smaller numbers led to larger force increase in the left than in the right hand in the numerical decision task (500–700 ms after stimulus onset). In the semantic task, smaller numbers again led to larger force increase in the left hand, and larger numbers increased the right-hand holding force. This effect appeared earlier (180 ms) and lasted longer (until 580 ms after stimulus onset). This is the first demonstration of SNAs with passive holding force. Our result suggests that (1) explicit motor response is not a prerequisite for SNAs to appear, and (2) the timing and strength of SNAs are task-dependent. (216 words).
... These sensors record force dynamics with millisecond resolution along three orthogonal axes, but only Fz force along the vertical axis through the sensors was analyzed and reported here. Two PCs were used: one for running the experiment under OpenSesame software [42] and another for force data acquisition under Expyriment software [43]. The first PC sent a trigger at the beginning of each trial to later identify a corresponding time point in the force data file. ...
Previous research demonstrated a close bidirectional relationship between spatial attention and the manual motor system. However, it is unclear whether an explicit hand movement is necessary for this relationship to appear. A novel method with high temporal resolution–bimanual grip force registration–sheds light on this issue. Participants held two grip force sensors while being presented with lateralized stimuli (exogenous attentional shifts, Experiment 1), left- or right-pointing central arrows (endogenous attentional shifts, Experiment 2), or the words "left" or "right" (endogenous attentional shifts, Experiment 3). There was an early interaction between the presentation side or arrow direction and grip force: lateralized objects and central arrows led to a larger increase of the ipsilateral force and a smaller increase of the contralateral force. Surprisingly, words led to the opposite pattern: larger force increase in the contralateral hand and smaller force increase in the ipsilateral hand. The effect was stronger and appeared earlier for lateralized objects (60 ms after stimulus presentation) than for arrows (100 ms) or words (250 ms). Thus, processing visuospatial information automatically activates the manual motor system, but the timing and direction of this effect vary depending on the type of stimulus.
... Auditors heard each phrase once only and could not change their response. Audio was presented, and ratings and response time were recorded using Expyriment (Krause and Lindemann, 2014). ...
Lateral vocalisation is assumed to arise from changes in coronal articulation but is typically characterised perceptually without linking the vocalised percept to a coronal articulation. Therefore, we examined how listeners' perception of coda /l/ as vocalised relates to coronal closure. Perceptual stimuli were acquired by recording laterals produced by six speakers of Australian English using electromagnetic articulography (EMA). Tongue tip closure was monitored for each lateral in the EMA data. Increased incidence of incomplete coronal closure was found in coda /l/ relative to onset /l/. Having verified that the dataset included /l/ tokens produced with incomplete coronal closure—a primary articulatory cue of vocalised /l/—we conducted a perception study in which four highly experienced auditors rated each coda /l/ token from vocalised (3) to non-vocalised (0). An ordinal mixed model showed that increased tongue tip (TT) aperture and delay correlated with vocalised percept, but auditors ratings were characterised by a lack of inter-rater reliability. While the correlation between increased TT aperture, delay, and vocalised percept shows that there is some reliability in auditory classification, variation between auditors suggests that listeners may be sensitive to different sets of cues associated with lateral vocalisation that are not yet entirely understood.
