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Results of cytological and colposcopic examination and p16ink4a and Ki-67 proteins expression in patients of groups 1 and 2 depending on HPV viral load
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Aim. To assess the feasibility of using immunocytochemical studies as a marker of proliferative activity in cervical intraepithelial neoplasia. Materials and methods. A comprehensive examination of 78 women, aged 25 to 45 years, with the presence of cervical intraepithelial neoplasia was carried out. Verification of the diagnosis was carried out on...
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Background
The aim of this study was to determine the prevalence of high-risk human papillomavirus (HR-HPV) and the correlation between multiple infections and cervical lesions.
Methods
The current study involved population-based sample of 20,059 women who underwent cervical screening for 15 HR-HPV genotypes with ThinPrep cytologic test (TCT) resu...
Citations
Introduction. Cervical cancer is one of the most common cancers of the female reproductive system, killing more than 250,000 women each year. The etiological agent that causes cervical cancer is well known. HPV infection with high oncogenic risk is the cause of more than 99% of cases of the disease. However, not all infections lead to cervical cancer: in the vast majority of women, the virus eliminates itself spontaneously within 2 years. Formation of HPV-associated cervical cancer depends on genetic and epigenetic factors, but the molecular pathogenesis of the disease is still insufficiently disclosed. The aim of the article is to analyze, systematize and summarize the available literature on the problems of prevalence, diagnosis, treatment, prevention, molecular genetic component. Material and methods. When writing this work, the main Internet resources were used: scientific electronic library (e-Library), Scopus, PubMed. The literature search was performed mainly for the previous 10 years. Results: The review contains articles describing genetic and epigenetic mechanisms of cervical cancer, modern methods of molecular-genetic diagnostics, as well as available statistical data on prevalence, prospects of prevention, diagnosis and treatment of this malignant disease.