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Results for flow around and within a clot with platelets represented as discrete elements. Base clot model, created based on experimental data, is modified to generate clots with varying microstructure. Intra-thrombus flow is orders of magnitude less than extra-thrombus flow, and governed by morphology and microstructure of the clot.

Results for flow around and within a clot with platelets represented as discrete elements. Base clot model, created based on experimental data, is modified to generate clots with varying microstructure. Intra-thrombus flow is orders of magnitude less than extra-thrombus flow, and governed by morphology and microstructure of the clot.

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... this second case-study, the system described in [3] was employed as the model system, with a thrombus obtained from an injured mouse cremaster muscle, and reconstructed using discrete ele- ments with planar aspect ratio 1:0.6. For an inlet flow with peak centerline velocity of 2 mm/s, the flow field obtained using the devised fictitious domain approach (Section 2.3) has been presented in Fig: 2 (left). The observed peak extra-thrombus flow velocity is 3.2 mm/s, while peak intra-thrombus velocity is around 3.29 µm/s. ...