Figure 1 - available via license: Creative Commons Attribution 3.0 Unported
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Representative BRCA1 IHC Stains. High power (40X) images. A: Retained BRCA1 IHC stain (>10% of tumor nuclei staining), B: Equivocal BRCA1 IHC stain (5%-10% of tumor cell nuclei staining) and C: Loss of BRCA1 (<5% of tumor nuclei staining).
Source publication
Objective:
The purpose of our study was to determine the frequency of BRCA1 promoter hypermethylation and its association with expression changes of BRCA1 and main morphological features in sporadic breast cancer.
Methods:
A retrospective review of cases was performed to select those with specific morphological features suggestive of breast canc...
Contexts in source publication
Context 1
... and equivocal samples were considered tumor and retained samples were considered normal. Figure 1 shows representative IHC stains of BRCA1. BRCA1 expression was retained in 30 non-cancerous breast tissue samples. ...
Context 2
... addition, three interesting predictions were revealed which might be associated with poor prognosis, although there was no association between tumor main pathological characteristics including; age, tumor stage, tumor size and BRCA1 hypermethylation. Firstly, Promoter hypermethylation was frequent (80%) in small size tumor (1-3 cm). Secondly, our study also demonstrated that the promoter methylation of BRCA1 gene is most common in tumor stage II (n= 22/30) and also relates to stage III (n= 8/30). ...
