Repetitive application of Serp-1 produces no obviously toxic effects. (A) Changes of body weight before and after experiments were measured and calculated (n = 5 for control group, n = 9 for Serp-1 group. *P < 0.05). (B) Histochemical analysis of eye cross-sections shows reduced rates of inflammatory cell infiltration and swelling of the cornea in Serp-1 treated mice. Enlarged images of the corneal region of two mice visibly show more swelling and a higher presence of inflammatory cells in the control mice. Inflammatory cell nuclei are stained by the deep-purple spots marked with white triangles in the light pink stromal layer of the cornea.