Figure
Relative organ weight of Wistar rats after repeated administration of D. steudneri Engl., aqueous extract.
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... weight (g/week) W0 W1 W2 W3 W4 Famale Control (10 mL/kg)compared to the negative control and also to the female groups. There was a significant reduction of the testis of male rats at 24.1 and 48.2 mg/kg (Table 5) for group of treated rats of both sexes and the control, and this was dose dependent. ...Similar publications
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Trees are unique in terms of development, sustainability and longevity. Some species have a record lifespan in the living world, reaching several millennia. The aim of this review is to summarize the available data on the genetic and epigenetic mechanisms of longevity in forest trees. In this review, we have focused on the genetic aspects of longev...
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Citations
... "The phytochemical components of herbal medicines play a crucial role in their therapeutic applications but can also be responsible for their toxicity if not properly managed" [18]. Therefore, scientific research is necessary to determine the safe dosage and therapeutic index of plant extracts containing various phytochemicals [19]. Studies evaluating the effects of C. odorata on animal models have shown adverse effects on kidney function and intestinal histology [20], secondary medical effects on the liver [21], and potential induction of spermatogenic arrest in male rats [22]. ...
Aim: The effect of chronic administration of ethanolic extract of Chromolaena odorata (C. odorata) on biomarkers of the cardiovascular system in Wistar rats was investigated in this study. Methods: Twenty male Wistar rats were randomly assigned to four groups of five animals each. Group 1 (control group) received only normal rat feed and distilled water, whereas groups 2, 3, and 4 received 250mg/kg, 500mg/kg, and 1000mg/kg body weight (b. w) of the extract, respectively. The treatment lasted 14 days. Results: The results showed a dose-dependent increase in the serum activity of Creatinine-kinase-MB (CK-MB) and Cardiac Troponin T (cTn-T) in the treated groups, but these increases were not statistically significant (p>0.05) compared to the control group. There were no significant (p>0.05) dose-related changes in the serum activities of Lactate dehydrogenase (LDH) and Tumor Necrosis Factor-alpha (TNF-α) in all treatment groups. However, serum Interleukin-1Beta (IL-1β) levels were significantly (p<0.05) lower in the higher dose groups. Histopathological examination of the heart did not reveal any significant morphological alterations in all treatment groups.
... "The phytochemical components of herbal medicines play a crucial role in their therapeutic applications but can also be responsible for their toxicity if not properly managed" [18]. Therefore, scientific research is necessary to determine the safe dosage and therapeutic index of plant extracts containing various phytochemicals [19]. Studies evaluating the effects of C. odorata on animal models have shown adverse effects on kidney function and intestinal histology [20], secondary medical effects on the liver [21], and potential induction of spermatogenic arrest in male rats [22]. ...
Aim: The effect of chronic administration of ethanolic extract of Chromolaena odorata (C. odorata) on biomarkers of the cardiovascular system in Wistar rats was investigated in this study. Methods: Twenty male Wistar rats were randomly assigned to four groups of five animals each. Group 1 (control group) received only normal rat feed and distilled water, whereas groups 2, 3, and 4 received 250mg/kg, 500mg/kg, and 1000mg/kg body weight (b. w) of the extract, respectively. The treatment lasted 14 days. Results: The results showed a dose-dependent increase in the serum activity of Creatinine-kinase-MB (CK-MB) and Cardiac Troponin T (cTn-T) in the treated groups, but these increases were not statistically significant (p>0.05) compared to the control group. There were no significant (p>0.05) dose-related changes in the serum activities of Lactate dehydrogenase (LDH) and Tumor Necrosis Factor-alpha (TNF-α) in all treatment groups. However, serum Interleukin-1Beta (IL-1β) levels were significantly (p<0.05) lower in the higher dose groups. Histopathological examination of the heart did not reveal any significant morphological alterations in all treatment groups.
