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Relationship Between Genetic Markers with Health Behaviors and Health Outcomes

Relationship Between Genetic Markers with Health Behaviors and Health Outcomes

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This paper examines the influence of health conditions on academic performance during adolescence. To account for the endogeneity of health outcomes and their interactions with risky behaviors we exploit natural variation within a set of genetic markers across individuals. We present strong evidence that these genetic markers serve as valid instrum...

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Context 1
... justify our four sets of genetic markers and two by their polygenic interactions to explain health behavior and status we begin by examining whether there are differences in health measures between individuals with different genetic markers. Table 3 presents information on summary measures for each genetic marker. That is, each cell contains the conditional mean, standard deviation and odds ratio of alternative health outcomes for individuals that possess a particular marker. ...
Context 2
... are limited efficiency gains and no substantial differences in the magnitude or significance of any of our results in this section moving from 2sls to 3sls. For completeness, 3sls results that correspond to Table 7 are presented in Appendix Table 3. The only minor change is that in the full sample with health vector 1, depression is now significant at the 10% rather the 5% level but the magnitude is virtually unchanged. ...
Context 3
... indicated in Appendix Table 3, which presents comorbidities by gender, there are substan- tially fewer girls diagnosed with both AD and HD relative to boys. Further, there are many more depressed females particularly in the early waves. ...

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... Due to the empirical challenges involved in assessing causality in the relationship, there is less agreement on what the precise mechanisms are that drive this correlation. As fi rst highlighted by Grossman (1973) and more recently by other authors including Cutler and Lleras-Muney (2006); Ding et al. (2006); Gan and Gong (2007), health and education may interact in three not mutually exclusive ways: ...
... These health conditions and risk factors tend to coincide with and affect each other, as indicated by the double-headed arrow connecting the left-hand boxes. One study illustrated this clearly: studying adolescents in the United States, Ding et al. (2006) found striking differences in the estimated impacts of depression and obesity when examining a single health state in isolation. That research also concluded that individuals with health disorders such as obesity or depression were signifi cantly more likely to smoke. ...
... Mediating factors include all those aspects determined by health that in turn can have an impact on educational outcomes e.g. (Ding et al., 2006): • cognitive and learning skills development • treatment received by children in the classroom in connection with their health condition(s) • discrimination by peers • self-esteem • students' physical energy. ...
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... references are:Norton et al. (1998); Salganik et al. (2008);Aral et al. (2009);Hogan and Lancaster (2004);Land and Deane (1992);Ding et al. (2006);Fletcher and Lehrer (2009); Langbehn et al. (2004); Visal-Puig et al. (1996);Greene (2003);Hardin and Carroll (2003);Hogan et al. (2004); and Noel and Nyhan (2011).weighting for causal inference from longitudinal observational studies. ...
... but the effect is insignificant based on the weak-instrument robust confidence bounds. 20 18 See Fletcher and Lehrer (2009), Ding et al. (2006Ding et al. ( , 2009 and Norton and Han (2008) for other applications that use genetic markers as instruments. These studies use a similar approach to evaluate the instrument validity (Ding 2006;Ding et al. 2009;Fletcher and Lehrer 2009;Norton and Han 2008). ...
... 20 18 See Fletcher and Lehrer (2009), Ding et al. (2006Ding et al. ( , 2009 and Norton and Han (2008) for other applications that use genetic markers as instruments. These studies use a similar approach to evaluate the instrument validity (Ding 2006;Ding et al. 2009;Fletcher and Lehrer 2009;Norton and Han 2008). 19 Table A3 in the Appendix reports the full regression results along with the tests of the IV assumption and Table A4 reports the coefficients of the first stages of the 2SLS models. ...
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... These studies consistently find that childhood onset of externalizing problems such as conduct disorder or substance abuse are negatively associated with subsequent educational attainment, whereas the evidence is more variable for internalizing problems such as depression and anxiety [7,585960. Other studies also find that, among secondary school students, depression and attention deficit/hyperactivity disorder are negatively associated with academic measures such as grade point average [61] and verbal test scores [59,61]. Taking into account the adverse educational outcomes associated with adolescent mental disorders, it seems plausible that increased treatment of these illnesses has led to larger numbers of youth with mental disorders attending college. ...
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