Regulation by lncRNAs. a Transcriptional regulation: participating in chromosomal epigenetic modification and interacting with transcriptional complexes and DNA components to promote or repress gene transcription. b Post-transcriptional regulation: participating in pre-mRNA alternative splicing, regulating mRNA maturation, degradation, inactivation, or localization, sponging microRNAs to prevent them from combining with target mRNA. c Translational regulation: targeting mRNAs or recruiting related proteins to promote or inhibit translation. d Post-translational regulation: modulating protein folding, modification, stability, and interactions with other proteins

Regulation by lncRNAs. a Transcriptional regulation: participating in chromosomal epigenetic modification and interacting with transcriptional complexes and DNA components to promote or repress gene transcription. b Post-transcriptional regulation: participating in pre-mRNA alternative splicing, regulating mRNA maturation, degradation, inactivation, or localization, sponging microRNAs to prevent them from combining with target mRNA. c Translational regulation: targeting mRNAs or recruiting related proteins to promote or inhibit translation. d Post-translational regulation: modulating protein folding, modification, stability, and interactions with other proteins

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Traumatic optic neuropathy or other neurodegenerative diseases, including optic nerve transection, glaucoma, and diabetic retinopathy, can lead to progressive and irreversible visual damage. Long non-coding RNAs (lncRNAs), which belong to the family of non-protein-coding transcripts, have been linked to the pathogenesis, progression, and prognosis...

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... Figure 1 shows the main features of the course of apoptosis in glioblastoma. Recently, special attention has been paid to the relationship between the development of apoptosis and the epigenetic regulation of gene expression (methylation and histone modifications), post-transcriptional regulation (RNA modifications) and post-translation modification of proteins [131][132][133][134]. ...
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This review is devoted to changes in the post-transcriptional maturation of RNA in human glioblastoma cells, which leads to disruption of the normal course of apoptosis in them. The review thoroughly highlights the latest information on both post-transcriptional modifications of certain regulatory RNAs, associated with the process of apoptosis, presents data on the features of apoptosis in glioblastoma cells, and shows the relationship between regulatory RNAs and the apoptosis in tumor cells. In conclusion, potential target candidates are presented that are necessary for the development of new drugs for the treatment of glioblastoma.