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Regional helicity changes are significantly correlated with CITED4/DAPI expression a–c Simple linear regressions of CITED4/DAPI signal and helicity within the septum, lateral wall and averaged across all AHA sections. Black dots represent sedentary animals and red dots represent exercised animals. The blue line represents the total simple linear regression of both groups. *P < 0.05, **P < 0.01, ***P < 0.001. Data presented with mean and 95% confidence interval.
Both exercise-induced molecular mechanisms and physiological cardiac remodeling have been previously studied on a whole heart level. However, the regional microstructural tissue effects of these molecular mechanisms in the heart have yet to be spatially linked and further elucidated. We show in exercised mice that the expression of CITED4, a transc...