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Ranking of age-standardised DALY rates for all conditions with neurological health loss by GBD region in 2021 Regions are grouped by GBD super-region and alphabetically ordered. Individual conditions are ordered by global ranking from highest age-standardised DALY rates to lowest age-standardised DALY rates. Dementia represents Alzheimer's disease and other dementias. DALYs=disability-adjusted life-years. GBD=Global Burden of Diseases, Injuries and Risk Factors Study. *Rankings are isolated to disease DALYs due to neurological complications, as opposed to DALYs attributed to the entire condition.

Ranking of age-standardised DALY rates for all conditions with neurological health loss by GBD region in 2021 Regions are grouped by GBD super-region and alphabetically ordered. Individual conditions are ordered by global ranking from highest age-standardised DALY rates to lowest age-standardised DALY rates. Dementia represents Alzheimer's disease and other dementias. DALYs=disability-adjusted life-years. GBD=Global Burden of Diseases, Injuries and Risk Factors Study. *Rankings are isolated to disease DALYs due to neurological complications, as opposed to DALYs attributed to the entire condition.

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Background Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditio...

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... ten conditions that accounted for the greatest nervous system DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer, with stroke being the greatest contributor globally and in 19 of 21 GBD regions (table 2; figure 1). Notably, four of the top ten conditions were not included in our previous analyses of neurological burden: neonatal encephalopathy, diabetic neuropathy, neurological complications due to preterm birth, and autism spectrum disorder, which emphasises the effects of early life and childhood conditions on total nervous system health loss and the under-recognised effects on the peripheral nervous system. ...

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