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ROS levels in C. elegans after M27 treatment. (A–E) ROS levels in control, M (100 μmol·L⁻¹), M27-L (12.5 μmol·L⁻¹), M27-M (50 μmol·L⁻¹), and M27-H (100 μmol·L⁻¹) groups; (F) Relative fluorescence intensity of intracellular ROS in C. elegans from control, M, M27-L, M27-M, and M27-H groups. n = 30, x‾ ± s. *p < 0.05, **p < 0.01, ****p < 0.0001.

ROS levels in C. elegans after M27 treatment. (A–E) ROS levels in control, M (100 μmol·L⁻¹), M27-L (12.5 μmol·L⁻¹), M27-M (50 μmol·L⁻¹), and M27-H (100 μmol·L⁻¹) groups; (F) Relative fluorescence intensity of intracellular ROS in C. elegans from control, M, M27-L, M27-M, and M27-H groups. n = 30, x‾ ± s. *p < 0.05, **p < 0.01, ****p < 0.0001.

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Magnolol (M), a hydroquinone containing an allyl side chain, is one of the major active components of Houpoea officinalis for antioxidation and anti-aging. To enhance the antioxidant activity of magnolol, the different sites of magnolol were structurally modified in this experiment, and a total of 12 magnolol derivatives were obtained. Based on the...

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