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The geomagnetic field (GMF) is crucial for the survival and evolution of life on Earth. The weakening of the GMF, known as the hypomagnetic field (HMF), significantly affects various aspects of life on Earth. HMF has become a potential health risk for future deep space exploration. Oxidative stress is directly involved in the biological effects of...
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... the mechanisms underlying these effects are still not well understood. Here, we summarize published studies on the effects of HMFs on ROS within animal cells or organisms (Table 1), excluding studies on plants or micro-organisms. HMF generally reduced H 2 O 2 levels within cells, accompanied by changes in cell behavior and gene expression in in vitro studies (Table 1). ...Context 2
... we summarize published studies on the effects of HMFs on ROS within animal cells or organisms (Table 1), excluding studies on plants or micro-organisms. HMF generally reduced H 2 O 2 levels within cells, accompanied by changes in cell behavior and gene expression in in vitro studies (Table 1). HMF in the range of 0.2-0.5 µT inhibited the proliferation and eNOS expression in endothelial cells [38], while HMFs (0.5-2 µT) suppressed H 2 O 2 production in cancer cells and bovine pulmonary artery endothelial cells (PAEC). ...Context 3
... has shown that HMF affects the mitochondria and NOXs, which are responsible for producing ROS. HMF exposure also leads to reduced mitochondrial ∆Ψ m , decreased ATP production and mitochondria activity, elevated ROS levels, and disrupted Ca 2+ balance in cells (Table 1 and Figure 1). Under oxidative stress, ROS, especially H 2 O 2 , activate signaling pathways to initiate biological processes, while high levels of ROS result in damage to DNA, protein, or lipids. ...