Figure 1 - available via license: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Content may be subject to copyright.
RNS System patients and experimental system. (A) 3-dimensional reconstruction of neurostimulator and lead placement (red). Yellow dots are recording hippocampal depth lead electrodes. (B) Top Row. Head CT of Patient R1 with neurostimulator and left hippocampal depth and mesial temporal subdural lead electrodes (red arrows), coronal (left) and sagittal (right) views.
Source publication
Some patients with medically refractory focal epilepsy are chronically implanted with a brain-responsive neurostimulation device (the RNS ® System), permitting neurophysiological measurements at millisecond resolution. This clinical device can be adapted to measure hippocampal dynamics time-locked to cognitive tasks. We illustrate the technique wit...
Context in source publication
Context 1
... this IRB approved study, three patients previously implanted with the RNS System consented to engage in a cross-modal associative memory task, performed during testing sessions spanning several months. Real-time iEEG recording and integration with a testing platform was enabled by IRB-approved Research Accessories (RAs), permitting task-based study design and analysis (Figure 1). These adults with drug-resistant focal onset epilepsy were implanted with the RNS System in accordance with FDA-approved indication for use and for reasons completely independent of this research study. ...
Similar publications
Epilepsy associated with Rasmussen’s encephalitis (RE) is highly resistant to standard therapy and continues to present a therapeutic challenge. While epilepsy surgery remains the most effective management for patients with drug-resistant focal epilepsy and RE, hemispherotomy may debilitating consequences on adult patients. Here we present the outc...
