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Quercetin content in fruits and ratios to total flavonols and total flavonoids

Quercetin content in fruits and ratios to total flavonols and total flavonoids

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Flavonoids as bioactive compounds in vegetable foods have been the subject of numerous research projects. Quercetin, with its powerful antioxidant activity, has also been and is currently in the focus of studies on plant species identification, and on its role in healthy nutrition. The current literature sources provide diverse information on its c...

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... results for quercetin and total flavonols content (expressed as a sum of myricetin, quercetin and kaempferol) in Bulgarian fruits, determined by HPLC method were presented in Table 2 in mg/100 g fresh weight. All results complied with the requirements for food data representativeness as they were a mean value of duplicate analyses of a pool of 3 market samples. ...
Context 2
... table also contains the quercetin ratios to total flavonols (sum of myricetin, quercetin and kaempferol) determined by HPLC method, and to total flavonoids determined by a colorimetric method, expressed in percents (%).The results shown in Table 2 revealed that the data obtained by HPLC analytical methods were normally lower than those provided by non-specific colorimetric spectrophotometry and, in some cases, for example with sour cherries, only 1% of the total flavonoids were on the account of the flavonol quercetin. This could be explained by the fact that the total flavonoids assay reported also other classes of phenolic compounds which, in fruits, were most frequently anthocyanins, catechins and their forms associated with gallic acid. ...

Citations

... It is known that fruits and vegetables are a very rich source of flavonoids from the group of catechins and the flavonol quercetin (Tsanova-Savova et al. 2003, 2017, 2018Velcheva-Kuzmanova et al. 2007). At the same time, in the scientific literature, there are data on a number of medicinal plants that also contain flavonoids from the group of catechins and flavonol rutin, such as in Pentace burmanica (Duangyod et al. 2014); in Dandelion (Taraxacum officinale), in Hawthorn (Crataegus monogyna), in Chamomile (Matricaria chamomilla), etc. (Yoo et al. 2009;Sofic et al. 2010). ...
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Background : Medicinal plants are a rich source of antioxidant polyphenols and in particular flavonoids. Materials and methods : In the present study 5 Bulgarian medical plants and 5 food supplements, present at the Bulgarian market, are analyzed for their Total phenolic, Total flavonoids and selected individual flavonoids content. A HPLC method was developed and validated for simultaneous determination of (+)-catechin, (-)-epicatechin and rutin in plant and supplements, using PDA detection. Results : The results show that polyphenols in the selected food supplements are lower than those of the medical plants analyzed. Mentha piperita and Melissa officinalis have the highest polyphenols content (67.38 and 65.17 mg GAE/g; 54.59 and 57.76 mg RE/g respectively). Rutin was detected in all samples analyzed, reaching highest levels in Mentha piperita (7332.5 µg/g), followed by fruits of Sambucus nigra (2818.7 µg/g). Conclusion : The results of the study are a practical contribution to a more complete characterization of the polyphenolic composition in Bulgarian medicinal plants.
... It is one of the most extensively used bioflavonoids found to be present in more than twenty plant materials including fruits (mainly citrus), green leafy vegetables as well as many seeds, barks, broccoli, olive oil, apples, onions, green tea, red grapes, red wine, dark cherries and berries such as blueberries and cranberries. 4,5 Being a plantderived aglycone form of flavonoid glycosides, it has many nutritional benefits against a variety of disorders, including cardiovascular protection, has anticancer, antitumor, anti-ulcer, anti-allergy, anti-viral, anti-inflammatory activity, anti-diabetic, gastro protective effects, it is also antihypertensive, immunomodulatory and anti-infective. 6 Plant extracts/ compounds are considered ideal sources of bioactive molecules due to their ample availability and wide array of reducing metabolites. ...
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Green synthesis of AuNPs that have potential anticancer properties is relatively simple, cheap and eco-friendly compared to the conventional chemical/physical approaches. Quercetin is known for its antioxidant and anticancer properties, i.e., induction of apoptosis, tumour suppression, etc. This study aims to characterize and compare between two differentially synthesized Quercetin-Au-Nanoconjugates, Q-Au-NCTSC and Q-AU-NCLE using a pure biochemical reductant, trisodium citrate and its natural alternative, citrus lemon extract respectively. Antibacterial and anticancer effects of both the nanoconjugates would also be checked and compared to analyze whether the use of a lemon extract has any impact on its structure and functional properties. A series of physicochemical characterizations viz. UV-Vis spectrophotometry, DLS, Zeta Potential, FT-IR, and SEM of the nanoconjugates were done. Further, evaluation of in vitro antibacterial activity was done against two Gram-positive bacteria: Staphylococcus aureus; Bacillus Subtilis; and two Gram-negative bacteria: Pseudomonas aeruginosa; Klebsiella pneumonia and cytotoxicity efficacy were checked on breast cancer (MCF7) cell line. Effective reduction of Au +3 to Au 0 with quantum confinement in nano-regime was confirmed by a change of bulk colour of the HAu +3 Cl4 solution, whereas conjugation of Quercetin to AuNPs was confirmed by FTIR. DLS showed the average size of the Q-Au-NCTSC and Q-Au-NCLE are 30 nm and 35.6 nm, respectively. The Q-Au-NCLE has shown comparatively better stability and antibacterial activity. In the case of cytotoxicity study on MCF7 cell line, the Q-Au-NCLE showed better efficacy (cell death ~ 75%) with respect to Q-Au-NCTSC (cell death ~66%). Natural sources rich in citric acid would serve as the best alternative to tri-sodium citrate in the synthesis of Au-NPs and different nanoconjugates for biomedical applications.
... Quantitatively, okra fruit extracts has a total flavonoid and quercetin content higher from green okra extract of 27.0 mg/100 g and 20.03 mg (QE)/100 g [49,50]. The green okra fruits contain of flavonoid such as a quercetin derivative. ...
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Diabetes mellitus is a group of metabolic disorders characterized by high blood-glucose levels over a prolonged period that causes complications when an open wound is present. Alginate is an antioxidant and a good absorbent of exudates. Okra fruit contains flavonoids that can act as antioxidants. The antioxidant properties of extracts combination reduce blood-glucose levels significantly to accelerate the activities of wound-healing processes on diabetic mice. Alginate was characterized by Size Exclusion Chromatography-Multiple Angle Laser Light Scattering (SEC-MALLS), thermal stability and Proton Nuclear Magnetic Resonance (1H-NMR). The evaluation of wound healing on 36 male mice were divided into 12 groups including normal control (NC), diabetics control (DC), alginate (DA) and alginate–okra (DAO) groups in three different times by histopathology test on skin tissue. The results of SEC-MALLS analysis showed that alginate as single and homogeneous polysaccharide. The 1H-NMR spectrum showed that the mannuronate/guluronate ratio of the used alginate was 0.91. Alginate, okra fruit extract and their combination were classified as moderate and strong antioxidants. The numbers of fibrocytes, fibroblasts, collagen densities had significantly increased from three to seven days. In contrast, wound width, neutrophil, macrophages had significantly decreased at 14 days. The administration of extracts combination increased the re-epithelization of the wound area and wound-healing process on diabetic mice.
... The flavonoids content (FC) was assessed by the AlCl 3 colorimetric assay as by previous investigators. [55] Briefly, 500 μL( 1mg/mL) of the extracts were mixed with 2mLo fd istilled water and 150 μLo f5%N aNO 2 were added to it. After 5min of incubation at dark, 150 μLo f1 0% AlCl 3 were added. ...
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The objective of this study was to profile the chemical components and biological activities analysis of crude extract of Bryophyllum pinnatum and Oxalis corniculata . Results revealed that the analyzed plant materials encompass the high amount of total phenolic and flavonoids content and have significant antioxidant activities. Furthermore, methanol extracts are the potential source of α‐ amylase, α‐ glucosidase, lipase, tyrosinase and elastase inhibitors. High resolution mass spectrometry revealed the presence of diverse metabolites such as Quercetin 3‐O‐alpha‐L‐rhamnopyranoside, Myricetin 3‐rhamnoside, Bersaldegenin 1, 3, 5‐orthoacetate, Bryophyllin C, Syringic acid, Caffeic acid, p‐Coumaric acid, and Quercetin in B. pinnatum and Isoorientin, Swertisin, Apigenin 7,4'‐diglucoside, Vitexin, 4‐Hydroxybenzoic acid, Vanillic acid, Ethyl gallate, 5,7‐Dimethoxy‐3,3',4'‐trihydroxyflavone, and Diosmetin‐7‐O‐beta‐D‐glucopyranoside in O. corniculata. Our finding suggested that these two plant species have high medicinal importance and are potential source of inhibitors for modern pharmaceuticals, nutraceuticals and cosmetics industries.
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Antibiotic resistance in pathogenic bacteria to various types of antibiotics has resulted in the necessity of new effective strategies to get around this problem. In recent investigations, metal or metal oxide nanoparticles specifically silver nanoparticles (AgNPs) have been employed successfully to hinder antibiotic-resistant Gram-negative and Gram-positive bacteria. However, AgNPs at high concentrations have cytotoxicity for eukaryotic cells which, application of other biocompatible materials particularly plant secondary metabolites of curcumin and quercetin to reduce cytotoxicity is a critical affair. These compounds may be used directly or indirectly to produce AgNPs. In this regard, modified NPs by curcumin and quercetin have shown an increased therapeutic effect and biocompatibility and biodegredibility properties. Therefore, here, recent advances and challenges about antibacterial and biocompatibility properties of nanoformulation of AgNPs with curcumin and quercetin are presented.
Chapter
Natural products are infinite resources of phytochemicals which continue to serve humans as natural drugs since ancient times. Polyphenols are natural plant-derived pharmacologically active compounds which have potential therapeutic properties including antioxidant, anti-inflammatory, and antitumor. Edible plants particularly phytochemicals and their biological activity in the human body is a trending subject of scientific investigations. Polyphenols are divided into three categories: flavonoids, non-flavonoids, and phenolic acids. Flavonoids have been further categorized as flavones, flavanones, flavonols, flavanols, and isoflavones, even as phenolic acids are classified into hydroxybenzoic and hydroxycinnamic acids. Polyphenols are bioactive compounds to manage the several autoimmune disorder such as vitiligo, ulcerative colitis, and multiple sclerosis through eliciting various intracellular pathways specifically (NF-κB), signaling pathway, mitogen-activated protein kinases (MAPKs) pathway, and phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. This chapter tends to provide a new insight into biomedical application of polyphenol for cancer, UTIs, diabetes, cardiovascular disorders, and neurodegenerative disorders.
Chapter
Phenolic compounds are widely distributed among plant fruits. They are present in fruits, vegetables, nuts, seeds, leaves, flours, roots, beverages and their derivative products. Phenolic compounds present in foods include phenolic-acids, hydroxycinnamic-acids, phenylethanoids, flavonoids, anthocyanins, tannins and lignans along with their composition have been discussed. Literature showed that flavonoids and anthocyanins in fruits received greater attention as compared to other phenolic compounds.
Chapter
Vegetables are an important component of our daily diet. Phenolic compounds are present in both free as well as bound forms in vegetables. Bound phenolic compounds are in the form of β-glycosides. Simple phenols, hydroxybenzoic acid, its aldehydes, cinnamic acids, its aldehydes, esters and alcohols, coumarins, chromones, flavonoids, and anthocyanins have been reported in nearly all vegetables. Cinnamic acids, their derivatives, flavonoids, and anthocyanins were the major classes of phenolic compounds. The presence of these phenolic compounds imparts significant antioxidant and medicinal activities.