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Prior EtOH exposure results in a near elimination of the aversive oromotor responses
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Background: Intermittent access to ethanol (EtOH) drives persistent escalation of intake and rapid transition from moderate to compulsive-like drinking. Intermittent EtOH drinking may facilitate escalation in part by altering aversion-sensitive neural substrates, such as the insular cortex (IC), thus driving greater approach toward stimuli previous...
Contexts in source publication
Context 1
... responses to intraoral EtOH infusions were quantified for the first minute of the taste reactivity video recording. Independent samples t-tests revealed that animals previously exposed to EtOH displayed more appetitive responses elicited by intraoral 20% EtOH infusion (Fig 2A); however, this was not statistically significant (t (15) = 1.67; p= 0.114). ...
Context 2
... finding that rats voluntarily increased lick rate to these higher concentrations is demonstrative of a substantive change in the evaluation of concentrated EtOH. Consistent with this interpretation, EtOH-exposed rats displayed significantly reduced aversive oromotor taste reactivity (Berridge, 2000, Grill and Norgren, 1978, Grill and Berridge, 1985 responses to intraorally delivered 20% EtOH, relative to naïve rats, indicating that the aversive properties of EtOH were specifically impacted following (Fig 2). It was previously demonstrated that more prolonged exposure to EtOH produced a similar decrease in aversive responding to EtOH, albeit at a lower concentration (12% vs 20%; Kiefer and Dopp, 1989) Subsequent quantification of FLI+ neurons across three anterior-posterior sections of IC revealed alterations in neural responsivity to intraoral 20% EtOH, which agrees with these behavioral effects. ...
Context 3
... are three key perceptual domains along which taste stimuli can vary: hedonics, intensity, and quality (Spector, 2000). Data from the BAEE paradigm (Fig 1) and taste reactivity measures (Fig 2) conclusively demonstrate that EtOH-exposed rats differ from naïve rats in their hedonic responding to EtOH, so we designed two experiments to independently test for differences in ...
