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Preservative systems used in challenge test. 

Preservative systems used in challenge test. 

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Table 1: Formulation tested in challenge test with several preservative...
Table 2: Preservative systems used in challenge test. 
Table 3: Chelating agents used to show the effect on the efficacy of...
Figure 3: Test results showing the boosting effect of different...
Boosting efficacy of preservatives
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  • Sep 2008
The topic of preservation is always of importance to formulators and finished goods marketers. Formulators are aware of the necessity to adequately preserve their products in order to ensure product safety and be in compliance with legislation. This task is made much more difficult when marketing requirements are added to the factors influencing th...
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Context 1
... has a surfactant-like structure. Due to this structure, ethylhexylglycerin affects the interfacial tension at the cell membrane of microorganisms, allowing some active ingredients, such as antimicrobials and Boosting efficacy of preservatives Preservative (see Table 2 for systems used) ...
Context 2
... 1 shows the tested formulation. Phenoxyethanol, methylisothiazolinone and methylparaben have been used as preservative actives (Table 2). ...

Citations

... Ethylhexylglycerin is used in cosmetics for its surfactant, emollient, mild humectant, perfume solubilizing and antimicrobial properties. Ethylhexylglycerin alone cannot preserve cosmetic products effectively but used at 1% concentration can enhance antimicrobial activity of synthetic preservatives, such as 1,2-pentanediol, phenoxyethanol, methylisothiazolinone or methylparaben [57]. Ethylhexylglycerin 0.5% (w/w) in combination with 1,2-pentanediol 3.0% (w/w) creates self-preserving formulations for leave-on cosmetics [55]. ...
... Moreover, antimicrobial efficacy of 0.5 and 1% Euxyl® PE 9010 (phenoxyethanol/ethylhexylglycerin) were comparable to efficacy of traditional preservative mixture (0.5 and 1% parabens in phenoxyethanol mixtures) for leave-on cosmetics [58]. Additionally, it has been shown that chelating agents with different doses (0.1 and 0.2%) may have an additional boosting effect on 0.75% Euxyl® PE 9010 and reduce the quantity of preservatives required to adequately protect cosmetic formulations [57]. It was also showed that 1% mixture of ethylhexylglycerin and caprylyl glycol (3:1 ratio) inhibited growth of bacteria and fungi in cosmetic emulsion [53]. ...
Antimicrobial Ingredients as Preservative Booster and Components of Self-Preserving Cosmetic Products
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Full-text available
This review reports cosmetic ingredients with antimicrobial activity including synthetic and natural (plant and microbial) origin as alternative for preservatives used in cosmetics as well described mechanism of their action.
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