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Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart for the included studies.
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Background
Intravenous alteplase (ALT) is the standard treatment for acute ischemic stroke (AIS). However, recent trials comparing other tissue plasminogen activators (tPAs) like tenecteplase (TNK) and reteplase with ALT have yielded conflicting results. This necessitated a network meta-analysis to compare the efficacy and safety of various tPAs i...
Contexts in source publication
Context 1
... title and abstract screening, 1561 studies were excluded, leaving 127 articles for full-text evaluation. After applying the predefined inclusion criteria, 16 randomized controlled trials (RCTs) were identified and selected for quantitative analysis (6,7,(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25), as illustrated in the PRISMA flowchart ( Figure 1). ...
Context 3
... the six interventions, 18 + 18 mg reteplase had the highest probability of being the best treatment (P-score=0.9638), while 0.1 mg/kg TNK had the least probability of being the best (Pscore=0.1523) (Table 3, Supplementary Figure 1A). The between-study variance (τ2\tau^2 = 0.0020) indicates low heterogeneity, suggesting consistent treatment effects across studies with minimal unexplained variability (Supplementary Table 3). ...
Context 4
... the six interventions, 18 + 18 mg reteplase had the highest probability of being the best treatment (P-score=0.9749), while 0.1 mg/kg TNK had the least probability of being the best (P-score=0.1995) (Table 3, Supplementary Figure 1B). The between-study variance for the outcome of independent ambulation (τ2\tau^2 = 0.0025) reflects low heterogeneity, indicating minimal unexplained variability and consistent treatment effects across the included studies (Supplementary Table 3). ...
Context 5
... had the highest probability of being the best treatment (P-score=0.8060), while 0.1 mg/kg TNK had the lowest (Pscore=0.0227) (Table 3, Supplementary Figure 1C). For the outcome of s-ICH, the between-study variance (τ2\tau^2 = 0.0945) indicates low to moderate heterogeneity across the included studies (Supplementary Table 3). ...
Context 6
... the six interventions, 12 + 12 mg reteplase had the highest probability of being the best treatment (P-score=0.7917), while 0.4 mg/kg TNK had the least probability of being the best (P-score=0.0701) (Table 3, Supplementary Figure 1D). The between-study variance was τ2\tau^2 = 0.0439, indicating low heterogeneity (Supplementary Table 3). ...
Context 7
... the six interventions, 0.1 mg/kg TNK had the highest probability of being the best treatment (P-score=0.6471), while 0.4 mg/kg TNK had the least probability of being the best (Pscore=0.2796) (Table 3, Supplementary Figure 1E). For the outcome of all-cause mortality, the between-study variance was τ2\tau^2 = 0.0631, indicating low to moderate heterogeneity (Supplementary Table 3). ...
Context 8
... the six interventions, 0.25 mg/kg TNK had the highest probability of being the best treatment (P-score=0.8543), while 0.1 mg/kg TNK had the least probability of being the best (P-score=0.1098) ( Table 3, Supplementary Figure 1F). For the outcome of early neurological development, the between-study variance was τ2\tau^2 = 0.0045, indicating low heterogeneity (Supplementary Table 3). ...
Context 9
... title and abstract screening, 1561 studies were excluded, leaving 127 articles for full-text evaluation. After applying the predefined inclusion criteria, 16 randomized controlled trials (RCTs) were identified and selected for quantitative analysis 6,7,[13][14][15][16][17][18][19][20][21][22][23][24][25] , as illustrated in the PRISMA flowchart ( Fig. ...
Context 10
... the six interventions, 18 + 18 mg reteplase had the highest probability of being the best treatment (P-score=0.9638), while 0.1 mg/kg TNK had the least probability of being the best (P-score=0.1523) ( Table 3, Supplementary Fig. 1A). The between-study variance (τ2\tau^2 = 0.0020) indicates low heterogeneity, suggesting consistent treatment effects across studies with minimal unexplained variability (Supplementary Table 3). ...
Context 11
... 0.1 mg/kg TNK had the least probability of being the best (P-score=0.1995) ( Table 3, Supplementary Fig. 1B). The between-study variance for the outcome of independent ambulation (τ2\tau^2 = 0.0025) reflects low heterogeneity, indicating minimal unexplained variability and consistent treatment effects across the included studies (Supplementary Table 3). ...
Context 12
... the six interventions (including between TNK and reteplase) yielded non-significant results (Table 2C) in addition to the non-significant local inconsistencies between direct and Table 2). ALT had the highest probability of being the best treatment (P-score=0.8060), while 0.1 mg/kg TNK had the lowest (P-score=0.0227) (Table 3, Supplementary Fig. 1C). For the outcome of s-ICH, the between-study variance (τ2\tau^2 = 0.0945) indicates low to moderate heterogeneity across the included studies (Supplementary Table ...
Context 13
... the six interventions, 12 + 12 mg reteplase had the highest probability of being the best treatment (P-score=0.7917), while 0.4 mg/kg TNK had the least probability of being the best (P-score=0.0701) (Table 3, Supplementary Fig. 1D). The between-study variance was τ2\tau^2 = 0.0439, indicating low heterogeneity (Supplementary Table 3). ...
Context 14
... the six interventions, 0.1 mg/kg TNK had the highest probability of being the best treatment (P-score=0.6471), while 0.4 mg/ kg TNK had the least probability of being the best (P-score=0.2796) ( Table 3, Supplementary Fig. 1E). For the outcome of all-cause mortality, the between-study variance was τ2\tau^2 = 0.0631, indicating low to moderate heterogeneity (Supplementary Table 3). ...
Context 15
... the six interventions, 0.25 mg/kg TNK had the highest probability of being the best treatment (P-score=0.8543), while 0.1 mg/kg TNK had the least probability of being the best (Pscore=0.1098) ( Table 3, Supplementary Fig. 1F). For the outcome of early neurological development, the between-study variance was τ2 \tau^2 = 0.0045, indicating low heterogeneity (Supplementary Table 3). ...
