Figure 4 - uploaded by Conchita Fraguas Bringas
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Predicted Rs3367 SARS-like bat CoV interactions with ACE2 receptor. (A) The surface structure of ACE2 (shown in cyan; PDB code: 6LZG, chain A) (19) complexed with the receptor binding domain (RBD) model of SARS-like bat Rs3367 coronavirus (salmon) viewed in Chimera (20), with key contact areas shown with black circles. (B) ACE2 surface- RBD interactions of conserved Y505 (COVID-19) and N501 (COVID-19) residues in SARS-like Rs3367 viral strain (top panel; shown in neon green) and in COVID-19 (bottom panel; shown in purple). White residues in the top panel represent the composition of the ACE2 pocket (13) interacting with N488.
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