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Cancer is a malignant disease that is characterized by rapid and uncontrolled formation of abnormal cells which may mass together to form a growth or tumor, or proliferate throughout the body. Next to heart disease, cancer is a major killer of mankind. This study aims at a preliminary phytochemical screening and anticancer evaluation of Adiantum ve...

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... Animals with cancer may live longer if nutritive fluid volume is reduced and tumour growth is stopped. A similar effect was shown in EAC-bearing mice treated with OI extract (20). The plant extract was successful in lowering the ascites fluid volume, increasing the percentage of life span, and decreasing the number of viable cells, all of which support its anticancer capabilities. ...
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Introduction and Aim: Constant efforts are exerted to explore unique bioactive principles from natural sources that possess more effective and specific antineoplastic activities. In the present study, we aimed to evaluate the antitumor activity of stem bark extract of Oroxylum indicum in mice bearing Ehrlich ascites carcinoma (EAC). Materials and Methods: Ninety female Swiss albino mice were categorized into fifteen groups (n=6). The animals were inoculated with 1x106 EAC cells. Tumor control animals received sterile water once daily for 10 consecutive days. Positive control group was injected with Cisplatin (CP) (one dose – 3.5 mg/kg body weight). The treatment groups were administered with O. indicum (OI) stem bark ethanol extract once daily with 50mg/kg, 200mg/kg and 400mg/kg body weight for eleven consecutive days. The blood parameters and serum hepatic enzymes activity was determined. The percentage increase in weight, the median survival time, the increase in median life span was calculated. The cytotoxic effect of CP and OI extract was determined. Results: There was significant reduction in the white blood cells count in OI and CP treatment group compared to increased level in EAC control group. The RBC count and Hemoglobin level which was significantly decreased (p<0.05) in the tumour mice, was enhanced in the drug treatment groups. The EAC control group showed significant increase in tumour cell count (p<0.05) whereas, treatment of EAC tumor bearing mice with OI and CP significantly increased the non-viable tumor cell count (p<0.05). Conclusion: OI stem bark ethanol extract reduced the toxic implications of Ehrlich ascites carcinoma, reverted the haematological and biochemical changes induced by tumour. These results call for additional research on isolating and identifying the responsible bioactive elements in order to clarify the underlying processes of the anticancer impact.
... Myelosuppression and anemia are the major problems in cancer chemotherapy. Anemia in tumor-bearing mice may be due to iron deficiency, hemolytic, or myelopathic condition [16]. Treatment with EASL restored the Hb levels, RBC and WBC counts to near normal levels ( Table 2), which indicates that the extract may possess protective effect on hematopoietic system. ...
Article
Objective: The present study aims to evaluate the anticancer potential of ethanolic extract of Alangium salvifolium leaves (EASL) against Ehrlich ascites carcinoma (EAC) in animal model. Methods: The ethanolic extract of A. salvifolium was prepared by continuous method using Soxhlet apparatus. Phytochemical analysis of EASL was conducted. Anticancer activity of the extract was evaluated by EAC model in Swiss albino mice. EASL was administered at the doses of 100 and 200 mg/kg body weight once a day orally for 14 days, after 24 h of tumor inoculation. Results: A. salvifolium leaves extract treatment produced significant decrease in tumor volume and body weight, and increase in total and non-viable cell count, along with elevated life span of EAC-bearing mice. The EASL exhibited potent dose-dependent antitumor activity. Further, the altered hematological parameters such as red blood cells, hemoglobin, and white blood cells levels as well as biochemical parameters such as serum glutamic oxaloacetic transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase, albumin, and total protein levels in EAC mice were significantly (p<0.05) regained following treatment with EASL. The anticancer potential of EASL can be attributed to the presence of phenols and flavonoids. Conclusion: Results suggest that EASL possesses significant anticancer activity against EAC tumor-bearing Swiss albino mice.
... Guha et al., 2004;Singh et al., 2008;Reddy et al., 2001;Viral et al., 2011;Mahmoud et al., 1989;Nyarko et al., 2012 ،) ( ‫ضدمیکروبی‬ Mahran, 1999;Tantawy, 2003 ،) ( ‫ضدالتهاب‬ Mabeza & Macfarlane, 2003;Haider et al., 2011;Zhang et al., 2000 ‫ضدآلر‬ ،) ‫ژ‬ ( ‫ی‬ Yuan et al., 2013;Hussain et al., 2008 ‫ضددیابتی‬ ،) ( Ranjan et al., 2014;Ocvirk et al., 2013 ‫تنظیم‬ ،) ‫عمل‬ ‫کنندۀ‬ ‫تیروئید‬ ‫کرد‬ Vijayalakshmi & Kiran Kumar, 2013) Sundaram & Milner, 1993;Freshney, 2000;Durmaz et al., 1999;Chiba et al., 1998 . Kumar et al., 2014 ) . ...
... show notable anti-cancer properties (Lai et al., 2010). The antithiamin substances in brackens, such as astragalin, isoquercitrin, rutin, caffeic acid, and tannic acid have Lee and Lin, 1988;Silva et al., 1995;Sun et al., 1997;Lee et al., 1999;Lin et al., 2000;Su et al., 2000;Chen et al., 2005b;Gao et al., 2007;Li J et al., 2014;Li S 2014;Elda et al., 2015 35 Woerdenbag et al., 1996;Li et al., 1998Li et al., , 1999Viral et al., 2011 45 Guha et al., 1996 MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Polypodiaceae In vitro assay using platelet activating factor and leukotriene B(4) Liu et al., 1998 been identified as valuable natural constituents because of their antitumour or antioxidant properties (Kweon, 1986;Cai et al., 2004;Katsube et al., 2006). The ferns P. nipponica, Polypodium formosanum, Polypodium vulgare, Polypodium fauriei, Polypodium virginianum, Dryopteris crassirizoma, Adiantum monochlamys, and Oleandra wallichii have been shown to have anti-cancer activity (Konoshima et al., 1996). ...
... Methanol extracts of Pityrogramma calomelanos, D. quercifolia, and D. linearis exhibit antitumour and cytotoxic activity (Sukumaran and Kuttan, 1991;Shin and Lee, 2010;Zakaria et al., 2011;Milan et al., 2013). Extracts of Adiantum venustum also have anti-cancer activity, as demonstrated by Viral et al. (2011). The lycophytes, Selaginella willdenowii (Fig. 3d), Selaginella lepidophyla, Selaginella labordei, Selaginella moellendorffii, Selaginella delicatula, S. tamariscina, and Sellaginella doederleinii (Fig. 3e) were shown to have cytotoxic and antimutagenic effects due to the presence of bioflavonoids (Lee and Lin, 1988;Silva et al., 1995;Sun et al., 1997;Lee et al., 1999;Lin et al., 2000;Su et al., 2000;Chen JJ et al., 2005;Gayathri et al., 2005;Woo et al., 2005;Gao et al., 2007;Shi et al., 2008;Tan et al., 2009), while Pteris semipinnata (Fig. 4c) and P. multifida have cytotoxic effects due to the presence of diterpenes (Woerdenbag et al., 1996;Li et al., 1998Li et al., , 1999. ...
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The aim of this review was to explore the pharmacological activity of early tracheophytes (pteridophytes) as an alternative medicine for treating human ailments. As the first vascular plants, pteridophytes (aka, ferns and fern allies) are an ancient lineage, and human beings have been exploring and using taxa from this lineage for over 2000 years because of their beneficial properties. We have documented the medicinal uses of pteridophytes belonging to thirty different families. The lycophyte Selaginella sp. was shown in earlier studies to have multiple pharmacological activity, such as antioxidant, anti-inflammatory, anti-cancer, antidiabetic, antiviral, antimicrobial, and anti-Alzheimer properties. Among all the pteridophytes examined, taxa from the Pteridaceae, Polypodiaceae, and Adiantaceae exhibited significant medicinal activity. Based on our review, many pteridophytes have properties that could be used in alternative medicine for treatment of various human illnesses. Biotechnological tools can be used to preserve and even improve their bioactive molecules for the preparation of medicines against illness. Even though several studies have reported medicinal uses of ferns, the possible bioactive compounds of several pteridophytes have not been identified. Furthermore, their optimal dosage level and treatment strategies still need to be determined. Finally, the future direction of pteridophyte research is discussed.
... The plant is also used in combination with other plant species as expectorant, hypothermic, diuretic and in stomach ache (Haq 2012). Viral et al. (2011) carried out preliminary phytochemical screening and anticancer evaluation of A. venustum against Ehrlich Ascites Carcinoma in Swiss albino mice. The ethanolic extract of the plant possesses significant anticancer and antioxidant activity due to the presence of terpenoids and flavonoids. ...
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The knowledge of the use of medicinal plants has been acquired through the centuries by observing the nature and such plants are still valuable for human health care programme. Himalayan maidenhair (Adiantum venustum D.Don; Family: Pteridaceae), popularly known as 'Hansraj' or 'Hanspad', employed as an ingredient in several Ayurvedic and Unani system of medicine. The species possesses immense therapeutic as well as other potential uses and frequently grown as a decorative plant because of its delicate fronds. An overview is conducted on A. venustum with an objective to provide information on the essential aspects for further exploration in human benefits.
... In addition to the promising results discussed above, an ethanol extract of Adiantum venustum Don. was shown to increase the mean survival time in carcinoma-bearing mice relative to a positive control group treated with the established drug vincristine (Viral et al. 2011). ...
Article
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Ferns are an important phytogenetic bridge between lower and higher plants. Historically they have been used in many ways by humans, including as ornamental plants, domestic utensils, foods, and in handicrafts. In addition, they have found uses as medicinal herbs. Ferns produce a wide array of secondary metabolites endowed with different bioactivities that could potentially be useful in the treatment of many diseases. However, there is currently relatively little information in the literature on the phytochemicals present in ferns and their pharmacological applications, and the most recent review of the literature on the occurrence, chemotaxonomy and physiological activity of fern secondary metabolites was published over 20 years ago, by Soeder (Bot Rev 51:442–536, 1985). Here, we provide an updated review of this field, covering recent findings concerning the bioactive phytochemicals and pharmacology of fern species.
... It is significant that over 60% of currently used anticancer agents are derived from natural sources, including plants, marine organisms and microorganisms. 10 A wide variety of natural compounds possesses significant cytotoxic as well as chemopreventive activity through induction of apoptosis in cancer cells. 11 Plant extracts used in traditional medicine exhibit a similar property. ...
Article
Punica granatum L. var. granatum (Pomegranate), an herbaceous plant found in Iran, The aim of this study was to investigate the cytotoxic effects, induction of apoptosis, and the mechanism of cell death of ethanol extract from Punica granatum L. var. spinosa on the mouse fibrosarcoma cell line, WEHI-164. Various parts of the herbs were extracted from fruit using ethanol as the solvent, and the cytotoxicity and cell viability of the ethanolic extract were determined by the MTT assay. To determine whether necrosis or apoptosis is the predominant cause of cell death, cell death detection was performed using the ELISA method. The induction of apoptosis was confirmed using the terminal deoxynucleotidyl transferase- (TdT-) mediated dUTP nick end labeling (TUNEL) assay. Moreover, a sensitive immunoblotting technique was used to examine the production of Caspase-3 and Bcl2 proteins. Our findings suggested that the ethalonic extract of Punica granatum L. var. spinosa altered cell morphology, decreased cell viability, suppressed cell proliferation and induced cell death in a time- and dose-dependent manner in WEHI-164 cells (IC50 = 229.024μg/ml), when compared to a chemotherapeutic anticancer drug, Toxol (Vesper Pharmaceuticals), with increased nucleosome production from apoptotic cells. Induction of apoptosis by the plant extract was proved by the decrease of pro-Caspase-3 and Bcl2 proteins and quantitatively confirmed by Immunoblotting analysis. The results obtained from the present study have demonstrated the growth-inhibitory effect of Ethanol Extracts from Punica granatum L. var. spinosa, and clearly showed that apoptosis was the major mechanism of in-vitro cell death induced by the extract.
... was closely observed for the first 3hrs then at an mice. Prolongation of life span of animals is the steadfast Hematological parameters (Figure 1) of tumor bearing criteria for judging the potency of any anticancer drug mice were found to be significantly altered compared to [16]. It can therefore be inferred that MAPV increased the the normal group. ...
Article
The present study is aimed to evaluate the methanolic fractions of the aerial parts of Polygonum viscosum (MAPV) for antitumor activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Twenty four hours after intraperitoneal inoculation of tumor (EAC) cells in mice, MAPV was administered at 50, 100 and 200 mg/kg body weight for nine consecutive days. On day 10 half of the mice were sacrificed and rest were kept alive for assessment of increase in life span. The antitumor effect of MAPV was assessed by evaluating tumor volume, packed cell count, viable and non-viable tumor cell count, median survival time and increase in life span of EAC bearing mice. Hematological profiles and serum biochemical parameters were estimated. MAPV showed a significant (p<0.05) decrease in tumor volume, packed cell volume and viable cell count and increased the life span of EAC bearing mice. Hematological and serum biochemical profiles were restored to normal levels in MAPV treated mice as compared to EAC control mice. The present study demonstrates that ethylacetate fraction of Polygonum viscosum leaves exhibited remarkable antitumor activity that is plausibly attributable to its augmenting endogenous antioxidant mechanisms.
... Plants have a long history of use in the treatment of cancer and they have played a vital role as a source of effective anticancer agent. It is significant that over 60% of currently used anticancer agents are derived, in one way or another, from natural sources, including plants, marine organism, and microorganisms [2]. The use of bioassay offers various scientific strategies like screening of extracts, fractions and compounds obtained from plants, which are often used in phytochemical research [3]. ...
Article
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Quercetin was isolated from an ethanol extract of Carmona retusa (Vahl.) Masam and was analyzed for its anticancer activity on HepG2 cell lines by MTT assay, Hoechst 33342 staining and Caspase-3 colorimetric assay. Plant extract yield of flavonoid quercetin from Carmona retusa (Vahl.) Masam showed significant and concentration-dependent anticancer activity at 100 µg/ml and 80 µg/ml doses after 24 and 48 h of treatment on HepG2 cell line in MTT assay, significant cell apoptosis have shown at 53µg/ml concentration of extract yield of flavonoid quercetin from Carmona retusa (Vahl.) Masam in Hoechst 33342 staining and a significant activation of caspase-3 observed at 100 µg/ml of extract yield of flavonoid quercetin from Carmona retusa (Vahl.) Masam after 24 h and even 48 h of incubation. Our findings suggesting that the plant extract yield of flavonoid quercetin from Carmona retusa (Vahl.) Masam could be used as a promising anticancer agent.
... Plants have a long history of use in the treatment of cancer and they have played a vital role as a source of effective anticancer agent. It is significant that over 60% of currently used anticancer agents are derived, in one way or another, from natural sources, including plants, marine organism, and microorganisms [2]. The use of bioassay offers various scientific strategies like screening of extracts, fractions and compounds obtained from plants, which are often used in phytochemical research [3]. ...
Article
Full-text available
Quercetin was isolated from an ethanol extract of Carmona retusa (Vahl.) Masam and was analyzed for its anticancer activity on HepG2 cell lines by MTT assay, Hoechst 33342 staining and Caspase-3 colorimetric assay. Plant extract yield of flavonoid quercetin from Carmona retusa (Vahl.) Masam showed significant and concentration-dependent anticancer activity at 100 µg/ml and 80 µg/ml doses after 24 and 48 h of treatment on HepG2 cell line in MTT assay, significant cell apoptosis have shown at 53µg/ml concentration of extract yield of flavonoid quercetin from Carmona retusa (Vahl.) Masam in Hoechst 33342 staining and a significant activation of caspase-3 observed at 100 µg/ml of extract yield of flavonoid quercetin from Carmona retusa (Vahl.) Masam after 24 h and even 48 h of incubation. Our findings suggesting that the plant extract yield of flavonoid quercetin from Carmona retusa (Vahl.) Masam could be used as a promising anticancer agent.