Figure 2 - uploaded by Enitome Bafor
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Photomicrographs of uterus, kidney, and liver sections stained with H/E and observed with a 40X objective. Control animals showing normal uterus histology with clear lamina propria (short arrow) are seen (A); mice treated with MOPS 5 g/kg also showed no change in uterus histology with defined endometrial glands (short arrow) (B). Control animals showed well defined renal corpuscles (short arrow). Some degree of inflammation (long arrow) is seen (C), while mice treated with MOPS 5 g/kg showed mild tubal necrosis (short arrow), and the renal corpuscles appeared slightly atrophied (long arrow) (D). The liver of control animals revealed prominent histology features showing centriole (long arrow) and hepatocytes (short arrow) (E). In contrast, treated animals showed centriole (long arrow) and focal areas of inflammatory and hydropic changes (short arrow). n =5 mice.
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... analysis revealed mild changes in some of the tissue architecture (Fig. 2). The uterus histology revealed no differences in tissue ( Figs. 2A and B ...
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... Its membership in the family of Sapotaceae, which are latex plants, may suggest possible toxicity. Indeed, Bafor et al. (2020), Adebayo et al. (2010) had already shown the toxic effects of methanolic extract of Omphalocarpum procerum sterm bark and ethanolic leaf extract of Chrysophyllum albidum respectively. Despite the large use of the extract of B. toxisperma in traditional medicine, there is a lack of studies related to their toxicity. ...
... The observed increase in granulocytes would confirm the possible inflammation mentioned with stomach atrophy, with granulocytes being strongly involved and their content increased in case of inflammation. Bafor et al. (2020), had already shown the proinflammatory effects of methanolic extract of Omphalocarpum procerum sterm bark. However, the extract could disrupt platelet and lymphocyte synthesis, resulting in low levels observed, which could result in coagulation disorders and decreased specific immunity (Arika et al., 2016). ...
Baillonella toxisperma Pierre, fruit pulp is largely used in traditional medicine. No toxicity study was done on this fruit pulp. The purpose of this study was to assess the acute and subacute toxicity of the hydroethanolic extract of the fruit pulp of B. toxisperma. An acute toxicity study was conducted at 2000 mg/kg of body weight as a 14-day limit test in Wistar albino rats. Throughout the experiment, general signs of toxicity were noted. Subsequently, a subacute toxicity study was performed at a dose of 400 mg/kg of body weight for 28 days. General signs of toxicity were also noted, after animal sacrifice, histological, hematological, and biochemical analyses (ALAT, ASAT, triglycerides, total cholesterol, total proteins, creatinine) were performed. At LD 50 ˃2000 mg/kg, no general signs of toxicity were noted in either acute or subacute conditions. No signs of toxicity were noted histologically, while slight increases in granulocytes and decreases in lymphocytes were noted hematologically. Biochemically, while no renal observations were made, the extract caused hepatic cytolysis. The fruit pulp of B. toxisperma P could be hepatotoxic at high doses.
