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Photograph of the patient, showing unilateral nevoid hyperkeratosis of the nipple and areola on the left breast, compared with the normal tissue of the right breast.
Source publication
Nevoid hyperkeratosis of the nipple and areola (NHNA) is a rare, benign condition of unknown origin that is characterized by a hyperpigmented, hyperkeratotic verruca plaque over the nipple and/or areola. NHNA usually occurs bilaterally, but is sometimes present unilaterally. We present a case of a 21-year-old Saudi female who presented at dermatolo...
Citations
... Primary or idiopathic and secondary. If it is accompanied by other skin lesions such as epidermal nevus, seborrheic keratosis, acanthosis nigricans, or the lesions that develop after drug use are called secondary type [5]. In our patients, there was no other skin lesions or medicine usage and her lesions are idiopathic. ...
Nevoid hyperkeratosis of the nipple and areola is an extremely rare and benign skin disease of unknown etiology, predominantly seen in childbearing aging women, especially in the second and third decades of life. The disease is characterized by gradually growing verrucous thickening and brown pigmentation of the nipple. Here, we present a case of nevoid hyperkeratosis of the nipple and areola in a 42-year-old female patient. Although nevoid hyperkeratosis of the nipple and areola has a benign character, it is a problem for patients due to deformity and for clinicians because of its similarity to paget disease. There is no consensus on treatment; Topical agents such as keratolytics, steroids, retinoids or calcipotriol, and ablative methods such as cryotherapy, carbon dioxide laser, radiofrequency, or shaving excision are treatment options.
Nevoid hyperkeratosis of the nipple and areola (NHNA) is a rare, benign, idiopathic condition, which occurs predominantly in women of child-bearing age. It is characterized by asymptomatic, hyperkeratotic, verrucous plaques, and either unilateral or bilateral over the nipple and areola. It has to be differentiated from Darier disease, seborrheic keratosis, atopic dermatitis, Paget's disease, frictional hyperkeratosis, and cutaneous T-cell lymphoma. Fused rete ridges, compact orthohyperkeratosis, and filiform papillomatosis are seen on histopathology. Dermoscopy shows keratotic structureless areas with brownish clods. There is no specific treatment, long-term use of calcipotriol and keratolytic agents for more than 6 months, and surgical therapy is recommended. This case is reported to highlight the use of dermoscopy in the diagnosis of NHNA.
