Figure 7 - uploaded by Ahmed Abbas Hussein
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Permeation of felodipine from LPHNs formulations HF1, HF4 and pure drug suspension through non-everted sheep intestine, the values of mean ±SD (n=3).
Source publication
The antihypertensive felodipine is a calcium-channel blocking agent. It is practically insoluble in water and shows low oral bioavailability (15%-20%). This investigation aims to formulate and characterize felodipine lipid polymer hybrid nanocarriers (LPHNs) to be given orally by two nanovesicles formulating methods and make comparative analysis th...
Context in source publication
Context 1
... outcomes of the ex vivo intestinal permeation experiment indicate that the permeability coefficient (cm/min) of felodipine was significantly higher (pvalue <0.05) for F3 and was significantly lower ( pvalue < 0.05) for pure drug suspension. The comparability profile of the felodipine release from LPHNs formulation (HF1-HF6) and the pure drug suspension explains in the following descending order: HF3 > HF 6 > HF 2 > HF 5 > HF 1 > HF 4 > pure drug suspension as shown in Figures (7,8,9). It was noted that the pure drug suspension gives a lower intestinal flux in comparison to all felodipine LPHNs formulations(HF1-HF6) due to increase solubility and intestinal permeation with felodipine LPHNs as lipid-based technology. ...
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