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Papillon-Lefèvre syndrome in a 6-year old child. A. Clinical manifestation of the extended periodontal inflammation affecting the primary dentition. B. Hyperkeratotic palmo-plantar skin lesions C-F. Radiographs showing the severe bone loss (arrows) around the teeth. Cultures of samples from the periodontal pockets revealed the rich presence (up to 70% of the total sample flora) of A. actinomycetemcomitans. (unpublished data of author SK). 

Papillon-Lefèvre syndrome in a 6-year old child. A. Clinical manifestation of the extended periodontal inflammation affecting the primary dentition. B. Hyperkeratotic palmo-plantar skin lesions C-F. Radiographs showing the severe bone loss (arrows) around the teeth. Cultures of samples from the periodontal pockets revealed the rich presence (up to 70% of the total sample flora) of A. actinomycetemcomitans. (unpublished data of author SK). 

Contexts in source publication

Context 1
... can also be developed in conjuction with systemic diseases or medication and its severity depends on the underlying condition, the most severe forms being found in patients with disorders in the cellular defense, mostly in neutrophils, e.g. Papillo-Lefèvre syndrome, Kostmann syndrome, various neutropenias, and Chediak-Higashi syndrome (Fig. 2) (Reichart & Dornow 1978;Deasy et al. 1980;Deas et al. 2003;Tempel et al. 1972;Saglam et al. 1995;Defraia & Marinelli 2001;De Vree et al. 2000). The etiology of periodontitis is microbial. The infection is caused in most cases by consortia of bacteria with a predominance of gram-negative anaerobic rods that colonize the periodontal ...
Context 2
... in the periodontium have been described as a "double-edged sword", capable of producing periodontal disease as well as protecting against the disease ( Lamster et al., 1992). Leukotoxin as well as leukotoxic bacteria have been shown to efficiently cause death of human PMNs and consequently the leukotoxin is assumed to protect A. actinomycetemcomitans against phagocytic killing (Henderson et al., 2010). The protection occurs in relation to the leukotoxin production of the bacterial population ( Johansson et al., 2000c). ...

Citations

... A. actinomycetemcomitans secretes leukotoxin, which was suggested to be in association between periodontitis and CVD. [25] Limitations such as inaccessible areas, residual sub-gingival pathogens and inability to eliminate the bacteria that penetrated the host tissues, led to the initiation of antimicrobial therapy along with mechanical debridement. Widespread use of common antimicrobials independently for different infectious conditions disturbs the delicate ecologic equilibrium of the body, allowing the proliferation of resistant bacteria, development of super infections and systemic toxic effects. ...
Article
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Context and Objective: Statin treatment, apart from its hypolipidemic action has proven its antimicrobial activity by improving the survival rate of patients with severe systemic bacterial infections. Periodontitis is an inflammatory disorder of tooth supporting structures caused by a group of specific microorganisms. The objective of the present study was to determine the antimicrobial activity of pure simvastatin drug against the primary periodontal pathogens. Materials and Methods: Minimum inhibitory concentration (MIC) was determined against Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans using serial dilution method. Results: MIC of simvastatin against P. gingivalis was 2 μg/ml and A. actinomycetemcomitans was found to be <1 μg/ml which requires further dilutions to determine the exact value. Conclusions: Data suggests a potent antimicrobial activity of simvastatin against both A. actinomycetemcomitans and P gingivalis. Hence simvastatin can be prescribed as a dual action drug in patients with both hyperlipidemia and periodontal disease.