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In recent years, there has been a growing interest in the role of the microbiome in cardiovascular and cerebrovascular diseases. Emerging research highlights the potential role of the microbiome in intracranial aneurysm (IA) formation and rupture, particularly in relation to inflammation. In this review, we aim to explore the existing literature re...
Contexts in source publication
Context 1
... several studies have investigated the microbiome's influence on stroke [17- 19,64], there are limited data on the role of the microbiome in IA formation and rupture. The studies discussed here are depicted in Table 1. [66] observed significant differences in the gut microbiome between patients with unruptured intracranial aneurysms (UIAs) and those with ruptured intracranial aneurysms (RAs). ...Context 2
... a database analysis of the gut microbiome of patients with UIAs and Ras, He et al. [67] identified three bacterial traits causally related to IAs and six bacterial traits related to UIAs (Table 1). Six bacterial traits were causally related to a decreased risk of subarachnoid hemorrhage (SAH) ( Table 1). ...Context 3
... a database analysis of the gut microbiome of patients with UIAs and Ras, He et al. [67] identified three bacterial traits causally related to IAs and six bacterial traits related to UIAs (Table 1). Six bacterial traits were causally related to a decreased risk of subarachnoid hemorrhage (SAH) ( Table 1). ...Similar publications
Background
Most hemodialysis (HD) patients suffer from hypertension and have a heightened cardiovascular risk. While blood pressure (BP) control is essential to end-stage kidney disease (ESKD) patients, overly stringent control can lead to intradialytic hypotension (IDH). This study aimed to examine BP variations during and after HD to determine wh...
Citations
... Last, little is known about the putative link between IA and GID, but it could be shown that depending on the gut and oral microbiota, there was either a protective or potential negative influence on the appearance of hemorrhagic stroke and IA pathophysiology in general (Joerger et al. 2023;Shen et al. 2023;Zhang et al. 2024). Despite the limited knowledge about the direct link between GID and IA, a substantial body of research supports the hypothesis of a strong influence/promotion of GID on neurological diseases, such as migraine, epilepsy, Parkinson's disease, cerebrovascular diseases, or multiple sclerosis (Barcellos et al. 2006;Casella et al. 2013;J. ...
Objective
The size of unruptured intracranial aneurysms (UIA) remains the most crucial risk factor for treatment decisions. On the other side, there is a non‐negligible portion of small ruptured IA and large stable UIA. This study aimed to identify the patients' characteristics related to IA size in the context of IA rupture status.
Methods
A total of 2152 patients, with 1002 being hospitalized for an acute aneurysmal subarachnoid hemorrhage (SAH), were included from our institutional IA database. Different demographic and clinical characteristics of patients and IA were collected. IA size was the study endpoint, assessed as continuous variable in univariate and multivariable linear regression analysis, separately for ruptured (R) IA and UIA.
Results
The mean IA size was 8.3 and 7.3 mm in the UIA and RIA subpopulations, respectively. Higher age (p = 0.003) and baseline blood urea level (p < 0.001) were independently associated with increasing UIA size. In contrast, location at the posterior circulation (p < 0.001), familiar intracranial aneurysms (p < 0.001), serum potassium (p = 0.006), and total serum protein (p = 0.019) were related to smaller UIA size in the multivariate analysis. For RIA, a statistically significant and independent association was detected for location (p = 0.019), history of gastrointestinal diseases (p = 0.042), and levothyroxine intake (p = 0.002).
Conclusions
Identification of clinical characteristics related to the size of ruptured and unruptured IA allows a more differentiated view on the genesis of RIA and UIA and the value of sack size as a basis for therapeutic decision‐making. More research is needed to verify the identified risk factors.
Background: Subarachnoid hemorrhage (SAH) risk increases with intracranial aneurysms (IA), but their relationship remains unclear. Methods: We explored SAH-IA links using machine learning and bioinformatics, identifying 66 IA-related SAH genes. KEGG analysis highlighted pathways like NF-κB, TNF, and COVID-19. Results: Two immune-related genes (ZNF281, LRRN3) were identified, and a ceRNA network was constructed. Ten potential SAH-IA drugs were screened via CMAP. Conclusion: ZNF281 and LRRN3 may regulate immune pathways (T cells, NK cells, macrophages), influencing IA-related SAH development, and could serve as therapeutic targets.
