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Background
Schistosoma haematobium and S. mansoni are endemic in Madagascar, but reliable diagnostic tools are often lacking, contributing to exacerbate transmission and morbidity. This study evaluated the diagnostic accuracy of three tests for schistosome infection in Malagasy adults from areas of medium to high endemicity.
Methods
This cross-sec...
Contexts in source publication
Context 1
... UCP-LF CAA and PCR (ρ = 0.44, 95% CI: 0.35-0.52). Table 2 presents the frequency of diagnostic test result combinations across three different methods (POC-CCA, UCP-LF-CAA, and PCR) in S. haematobium and S. mansoni endemic areas. Complete agreement of all three tests was observed in 41% of cases in the S. haematobium area (29% all positive, 12% all negative) and 57% in the S. mansoni area (35% all positive, 22% all negative). ...Context 2
... on Se, Sp, negative and positive predictive values and prevalence can be found in Supplementary Tables SI2.1-SI2.2 along with model comparisons (Table SI2.3). Sensitivity analyses using informative priors for test specificities and alternative trace result interpretation (Supplement 2.3, 2.4) confirmed the robustness of our findings regarding test performance characteristics. ...Similar publications
This article reports a case of urogenital schistosomiasis mimicking IgG4-related disease (IgG4-RD) in a 47-year-old immunocompromised man with HIV. Initially diagnosed with IgG4-RD, further biopsies revealed schistosoma eggs. Elevated IgG4 levels indicated a Th2 immune response, highlighting its complex role in antischistosomal immunity and the nee...
