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ORAL ANTIHISTAMINES AVAILABLE IN AUSTRALIA 3,4

ORAL ANTIHISTAMINES AVAILABLE IN AUSTRALIA 3,4

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Newer, less sedating antihistamines have largely superseded older antihistamines in the treatment of allergy. Is there still a role for older, first‑generation antihistamines?

Context in source publication

Context 1
... The article does not discuss agents such as antazoline, azelastine, levocarbastine or olopatadine used in eye drops or nasal sprays. Oral antihistamines currently available in Australia are listed in Table 1. 3,4 Indications and accepted uses Indications may vary from drug to drug, however both sedating and less sedating antihistamines are indicated for: 3 • allergic rhinitis; • urticaria; • other allergic conditions. ...

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Citations

... Firstgeneration antihistamines can antagonize acetylcholine at neuronal and neuromuscular muscarinic receptors, while second-generation antihistamines cannot [8]. Since second-generation antihistamines lack anticholinergic effects, they cannot alleviate a cough [9]. As a result, first-generation antihistamines are found in cough medicines and second-generation antihistamines are not [9]. ...
... Since second-generation antihistamines lack anticholinergic effects, they cannot alleviate a cough [9]. As a result, first-generation antihistamines are found in cough medicines and second-generation antihistamines are not [9]. Antihistamines act by decreasing the cholinergic transmission of nerve impulses in the coughing reflex thus suppressing the cough [10]. ...
... Nasal decongestants such as phenylephrine and pseudoephedrine are commonly used in combination medicines for alleviating a cough because they help in relieving nasal congestion [7]. A combination medicine containing a first-generation antihistamine and a nasal decongestant was found to relieve an acute cough and nasal congestion more effectively than a placebo, in one clinical trial [9]. One randomized clinical trial showed that naproxen, which is a Non-Steroidal Anti-inflammatory Drug (NSAID) was very effective in alleviating a cough hence this medicine can be investigated further before using it in practice [9]. ...