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Nutritional and cardiometabolic profile, and plasma curcuminoid levels

Nutritional and cardiometabolic profile, and plasma curcuminoid levels

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Purpose The consumption of products containing fructose is associated with metabolic disorders and nonalcoholic fatty liver disease (NAFLD). Several pathways have been described associating the fructose intake and liver damage, among them the reduced peroxisome proliferator-activated receptor alpha (PPAR-α) expression, insulin resistance, inflammat...

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... and cardiometabolic profile and plasma curcuminoid levels Table 1 shows the nutritional, cardiometabolic profile and plasma curcuminoid levels in both fructose and fructose + Cl groups. It is possible to verify that the treatment was effective to reduce HOMA-IR (fructose = 39.1 ± 10.9 vs fructose + Cl = 12.5 ± 5.4, p = 0.001) and triglyceride levels (fructose = 163 ± 44 vs fructose + Cl = 92 ± 21, p = 0.005). ...

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... The transformation of curcumin in unidentified complex throughout the absorption and its glucuronidation in liver possibly account for the low concentrations in the blood. The black pepper was found to result in the enhancement of drug bioavailability through inhibiting the glucuronidation in liver and small intestines (Hasimoto et al. 2020). ...
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Cystic echinococcosis (CE) has been defined as an illness that results from the larval Echinococcus granulosus stage. Treating cystic echinococcosis is fundamentally dependent upon using Albendazole that may typically result in negative side effects, which is why, more sufficient options of treatment being necessary. The re-purposing of the drugs has been considered as a beneficial method to advance the drug development. In vitro proto-scolicidal effect of the piperine and curcumin have been assessed in E. granulosus and expression of calmodulin (CaM) genes, both of them were linked to the cellular signaling activities. Based on the results, curcumin and piperine's have dose-dependent proto-scolicidal effects to achieve the optimal efficacy that the isolated piperine 20mg/k and 2g/k curcumin showed significant anthelminthic activity compared to the standard anthelminthic drug enhancing the bioavailability of curcumin. Calmodulin, as a dynamic Ca 2+ sensor, mediates various activities of the cellular signaling from E. granulosus will be possibly involved in a significant biological function.
... The transformation of curcumin in unidentified complex throughout the absorption and its glucuronidation in liver possibly account for the low concentrations in the blood. The black pepper was found to result in the enhancement of drug bioavailability through inhibiting the glucuronidation in liver and small intestines (Hasimoto et al. 2020). ...
Article
Full-text available
Cystic echinococcosis (CE) has been defined as an illness that results from the larval Echinococcus granulosus stage. Treating cystic echinococcosis is fundamentally dependent upon using Albendazole that may typically result in negative side effects, which is why, more sufficient options of treatment being necessary. The re-purposing of the drugs has been considered as a beneficial method to advance the drug development. In vitro proto-scolicidal effect of the piperine and curcumin have been assessed in E. granulosus and expression of calmodulin (CaM) genes, both of them were linked to the cellular signaling activities. Based on the results, curcumin and piperine's have dose-dependent proto-scolicidal effects to achieve the optimal efficacy that the isolated piperine 20mg/k and 2g/k curcumin showed significant anthelminthic activity compared to the standard anthelminthic drug enhancing the bioavailability of curcumin. Calmodulin, as a dynamic Ca 2+ sensor, mediates various activities of the cellular signaling from E. granulosus will be possibly involved in a significant biological function.