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Number of patients with different types of thalassemia in seven regions [11] 

Number of patients with different types of thalassemia in seven regions [11] 

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Early diagnosis of disease is highly recommended for the treatment purposes by the clinicians. Thalassemia is a genetic disorder which can be inherited from the parents. Thalassemia is classified into two groups alpha thalassemia and beta thalassemia depending upon the severity of the infants. The methods for early diagnosis of beta Thalassamia whi...

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... takes place in ribosomes to synthesis polypeptide chain according to the directions supplied by mRNA template. Messenger RNA (mRNA), transfer RNA (tRNA) and ribosomal RNA (rRNA) are involved in the synthesis of polypepetides. The DNA template will be transcribed into mRNA where transfer of genetic code occurs from the nucleus to the cytoplasm of erythroblasts to regulate the sequence of amino acids in the formation of polypeptide. Transfer RNA plays an important role where specific amino acids transported from cytoplasm to the specific locations (codons) along with mRNA strand. After translation process and synthesis of polypeptide chain by ribosomes, it transform into globin chain. Globin gene expression may alter during development to build different haemoglobin tetramers such as embryonic such as Hb Gower I (ζ2ε2), Hb Gower 2 (α2ε2) and Hb Portland (ζ2γ2), Hb fetal (α2γ2) and adult Hb A (α2β2) and Hb A2 (α2δ2). An appearance of clinical manifestation in hemoglobinopathies plays an important role in developmental alteration of globin genes expression. Alpha thalassemia can be identified at birth whereas beta thalassemia can be detected a few months after the birth [8]. Statistical data of the number of patients with alpha and beta thalassemia in seven regions are shown in Fig. 2. Beta thalassemia has the highest number in Asia and South East Asia, reaching 32665 patients and 21693 patients respectively . Beta thalassemia in Eastern Mediterranean has higher number than Pacific region about 9716 patients. Alpha thalassemia is also high in Asia region approximately 17708 patients, followed by Pacific region were 8267 patients. African region has high number of beta thalassemia about 1520 patients, followed by American and Europe region about 534 and 498 patients respectively. Alpha thalassemia has the lowest number in African, with 11 patients and Eastern Mediterranean about 1 patient only ...

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