Number of candidate genes from Scoary analysis in four genomic categories with significant correlation to resistance (P < 0.01 with both empirical P and Bonferroni correction) by the antibiotic tested.

Source publication

Canine E. coli pangenome (N = 1,778). (A) Roary (50) matrix containing...

Core genome phylogeny of E. coli sampled from dog hosts across US and...

Number of candidate genes from Scoary analysis in four genomic...

Group 1 CPS gene content from the 38 isolates carrying wza2 and wzi...

Heatmap generated from computed pairwise TM scores between WzaCA, Wza1,...

Evolutionary genomic analyses of canine E. coli infections identify a relic capsular locus associated with resistance to multiple classes of antimicrobials

Article

Full-text available

Jul 2024

Kristina Ceres
Jordan D. Zehr
Chloe Murrell
[...]
Laura B Goodman

Infections caused by antimicrobial-resistant Escherichia coli are the leading cause of death attributed to antimicrobial resistance (AMR) worldwide, and the known AMR mechanisms involve a range of functional proteins. Here, we employed a pan-genome wide association study (GWAS) approach on over 1,000 E. coli isolates from sick dogs collected across...