Neurobehavioral assessment tests in zebrafish.

Neurobehavioral assessment tests in zebrafish.

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Learning and memory are essential to organism survival and are conserved across various species, especially vertebrates. Cognitive studies involving learning and memory require using appropriate model organisms to translate relevant findings to humans. Zebrafish are becoming increasingly popular as one of the animal models for neurodegenerative dis...

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... main types of behaviors assessed in zebrafish as pharmacological models for learning and memory performance are locomotion, emotion (anxiety-like), cognition (learning, object recognition, spatial memory) and social interaction (preference, aggressiveness) [45]. (Table 2) There could be some variations when conducting a neurobehavioral paradigm in zebrafish to capture the change of innate behavioral response due to the drug treatment. For example, the habituation (familiarization) phase might be employed in a conditioning paradigm to reduce the anxiety or exploration of zebrafish toward novel environments. ...
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... and cognitively unimpaired zebrafish are models for screening compounds or conditions with memory enhancement (nootropic) properties [46,[84][85][86][87][88][89][90] (Supplemen- tary Table S2). Yoo et al. used zebrafish to screen for the nootropic effect of UTI [90]. ...

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