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Network comparisons of studies included in the network meta-analysis. (a) Frequency of attacks; (b) pain-free rate; (c) duration of attacks; (d) number of patients using rescue agents; (e) adverse events. Betamethasone (BET), Candesartan cilexetil (CAN), Capsaicin (CAP), Cimetidine (CIM), Civamide (CIV), Cortivazol (COR), Frovatriptan (FRO), Galcanezumab (GAL), Lithium carbonate (LCAR), Melatonin (MEL), Misoprostol (MIS), Octreotide (OCT), Placebo (PLA), Prednisone (PRE), Sumatriptan 6 mg (SUM6), Sumatriptan 12 mg (SUM12), Sumatriptan 100 mg (SUM100), Sumatriptan spray (SUMS), Valproate (VAL), Verapamil (VER), Warfarin (WAR), Zolmitriptan 5 mg (ZOL5), Zolmitriptan 10 mg (ZOL10). The size of each circle represents the proportion of the number of patients for each treatment and the width of the lines represents the proportion of the number of studies.

Network comparisons of studies included in the network meta-analysis. (a) Frequency of attacks; (b) pain-free rate; (c) duration of attacks; (d) number of patients using rescue agents; (e) adverse events. Betamethasone (BET), Candesartan cilexetil (CAN), Capsaicin (CAP), Cimetidine (CIM), Civamide (CIV), Cortivazol (COR), Frovatriptan (FRO), Galcanezumab (GAL), Lithium carbonate (LCAR), Melatonin (MEL), Misoprostol (MIS), Octreotide (OCT), Placebo (PLA), Prednisone (PRE), Sumatriptan 6 mg (SUM6), Sumatriptan 12 mg (SUM12), Sumatriptan 100 mg (SUM100), Sumatriptan spray (SUMS), Valproate (VAL), Verapamil (VER), Warfarin (WAR), Zolmitriptan 5 mg (ZOL5), Zolmitriptan 10 mg (ZOL10). The size of each circle represents the proportion of the number of patients for each treatment and the width of the lines represents the proportion of the number of studies.

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It is important to find effective and safe pharmacological options for managing cluster headache (CH) because there is limited evidence from studies supporting the general efficacy and safety of pharmacological therapies. This systematic review and network meta-analysis (NMA) analyzed published randomized controlled trials (RCTs) to evaluate the ef...

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Acute Mania; Rapid Cycling Bipolar Disorder; Bipolar II Disorder and Bipolar Depression; Bipolar Disorder Prophylaxis, Response Predictors; Unipolar Depression; Suicidality; Aggressive or Impulsive Behavior in Child/Adolescent Patients with Conduct Disorder, in Borderline Personality Disorder or in Patients with Intellectual Disability; Neuroprotective Properties; Elevation of Neutrophil Counts; Mechanisms of Action