NJ Phylogenetic tree of the five putative rhomboid families using Mega 5.0 (Bootstrap values <70 have been omitted). Colored boxes are indicative of rhomboid sequences from Streptomycetes, while the clear boxes are sequences of the same rhomboid family, but from other Actinomycetes.

NJ Phylogenetic tree of the five putative rhomboid families using Mega 5.0 (Bootstrap values <70 have been omitted). Colored boxes are indicative of rhomboid sequences from Streptomycetes, while the clear boxes are sequences of the same rhomboid family, but from other Actinomycetes.

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Proteolytic enzymes are ubiquitous and active in a myriad of biochemical pathways. One type, the rhomboids are intramembrane serine proteases that release their products extracellularly. These proteases are present in all forms of life and their function is not fully understood, although some evidence suggests they participate in cell signaling. St...