Fig 3 - uploaded by Silvio Buscemi
Content may be subject to copyright.
Muscle Mass Changes with Aging. Peak muscle mass occurs between the ages of 20 and 30 years, and naturally declines as one ages. Declining function parallels the concept of sarcopenia. Sarcopenia comes from the Greek word, “Sarcos” meaning flesh, and ‘penia’ meaning lack of. This age-related decline in lean body mass can affect ambulation, mobility, and functional independence (Morley et al. 2001). An analogy often used is the age-related decline in bone mass, where, once it reaches a critical level, one’s risk of fracture is increased. Sarcopenia can be conceptualized on the spectrum of frailty and disability and has been shown to be increasingly prevalent with age. More recently, the concept of declining strength has been incorporated into the definition, although, a widely accepted definition of sarcopenia has yet to be established (Cruz-Jentoft et al. 2010)). Sarcopenia indeed can be considered a geriatric syndrome. These are common, complex and costly entities of impaired health in elderly individuals which involve multiple systems, have a myriad of interactions, and have varied phenotypes. Falls, urinary incontinence and delirium are but some examples of such. Sarcopenia has also been associated with malnutrition and diminished physical function, both of which are associated with geriatric functional decline and mortality. The loss of muscle mass during the aging process is important clinically as it reduces strength and exercise capacity, both which are needed to perform one’s activity of daily living. It is hypothesized that subjects reach a given threshold at which impairment in function occurs. Absolute loss of muscle mass leads to reduced muscle function and hence physical performance measures are increasingly being used in the definition and identification of sarcopenia. There are a number of definitions outlined in the literature making standardization, particularly in clinical practice, rather difficult (Baumgartner et al. 1998; Bouchard, Dionne, and Brochu 2009; Davison et al. 2002; Zoico et al. 2004) . Prevalence rates can vary dramatically and is the subject of current investigation. This syndrome has a number of risk factors, a number that are 

Muscle Mass Changes with Aging. Peak muscle mass occurs between the ages of 20 and 30 years, and naturally declines as one ages. Declining function parallels the concept of sarcopenia. Sarcopenia comes from the Greek word, “Sarcos” meaning flesh, and ‘penia’ meaning lack of. This age-related decline in lean body mass can affect ambulation, mobility, and functional independence (Morley et al. 2001). An analogy often used is the age-related decline in bone mass, where, once it reaches a critical level, one’s risk of fracture is increased. Sarcopenia can be conceptualized on the spectrum of frailty and disability and has been shown to be increasingly prevalent with age. More recently, the concept of declining strength has been incorporated into the definition, although, a widely accepted definition of sarcopenia has yet to be established (Cruz-Jentoft et al. 2010)). Sarcopenia indeed can be considered a geriatric syndrome. These are common, complex and costly entities of impaired health in elderly individuals which involve multiple systems, have a myriad of interactions, and have varied phenotypes. Falls, urinary incontinence and delirium are but some examples of such. Sarcopenia has also been associated with malnutrition and diminished physical function, both of which are associated with geriatric functional decline and mortality. The loss of muscle mass during the aging process is important clinically as it reduces strength and exercise capacity, both which are needed to perform one’s activity of daily living. It is hypothesized that subjects reach a given threshold at which impairment in function occurs. Absolute loss of muscle mass leads to reduced muscle function and hence physical performance measures are increasingly being used in the definition and identification of sarcopenia. There are a number of definitions outlined in the literature making standardization, particularly in clinical practice, rather difficult (Baumgartner et al. 1998; Bouchard, Dionne, and Brochu 2009; Davison et al. 2002; Zoico et al. 2004) . Prevalence rates can vary dramatically and is the subject of current investigation. This syndrome has a number of risk factors, a number that are 

Context in source publication

Context 1
... normally occurs after the age of 20-30 years and can be extensive, involving up to 40% of a population ( Baumgartner et al. 1995;Flynn et al. 1989;Gallagher et al. 1997;Muller et al. 1996). As is demonstrated in Figure #3, maximal fat free mass (muscle mass) is usually reached at about 20 years of age and fat mass peaks at the ages between 60 and 70 years ( Baumgartner et al. 1995;Gallagher et al. 1997). ...

Similar publications

Article
Full-text available
Our study aimed to identify the factors associated with sarcopenia in older adults in the community. This is a correlational, cross-sectional study with a quantitative approach, conducted with 234 older people. We used the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP2) to assess sarcopenia and collected the following...
Article
Full-text available
COPD is associated with a progressive loss of muscle mass and function. However, there is an unmet need to define and standardise methods to estimate the prevalence of sarcopenia in COPD patients. We performed a systematic review and meta-analysis of the prevalence of this extrapulmonary manifestation in COPD patients. We searched Embase, Medline (...
Article
Full-text available
Risk assessment is relevant to predict outcomes in patients with gastric cancer. This systematic review aimed to investigate the predictive value of low muscle mass for postoperative complications in gastric cancer patients. A systematic literature search was performed to identify all articles reporting on muscle mass as measured on computed tomogr...
Article
Full-text available
Background: Handgrip strength (HGS) is an indicator of muscular strength, used in the diagnosis of sarcopenia, undernutrition, and physical frailty as well as recovery. Typically, the maximum HGS value is used; however, recent evidence suggests the exploration of new indicators provided based on the force–time curve to achieve a more comprehensive...

Citations

... It is well established that aging is associated with reduced physical activity and muscle mass (Batsis and Buscemi 2011) resulting in decreased balance, stability and mobility (Onambele et al. 2006). This age-related decline in function is also linked to a reduction in the mechanical properties of the tendon, possibly due to intrinsic modifications of the tendon microstructure and/or cross-linking with aging (Nordez et al. 2009;Svensson et al. 2016;Quinlan et al. 2018;Magnusson and Kjaer 2019). ...
Article
Full-text available
The aim of this study was to investigate the effect of aging and resistance training with a moderate load on the size and mechanical properties of the patellar (PT) and Achilles tendon (AT) and their associated aponeuroses; medial gastrocnemius (MG) and vastus lateralis (VL). Young (Y55; 24.8 ± 3.8 yrs, n = 11) and old men (O55; 70.0 ± 4.6 yrs, n = 13) were assigned to undergo a training program (12 weeks; 3 times/week) of moderate slow resistance training [55% of one repetition maximum (RM)] of the triceps surae and quadriceps muscles. Tendon dimensions were assessed using 1.5 T magnetic resonance imaging before and after 12 weeks. AT and PT cross sectional area (CSA) were determined every 10% of tendon length. Mechanical properties of the free AT, MG aponeurosis, PT, and VL aponeurosis were assessed using ultrasonography (deformation) and tendon force measurements. CSA of the AT but not PT was greater in O55 compared with Y55. At baseline, mechanical properties were generally lower in O55 than Y55 for AT, MG aponeurosis and VL aponeurosis (Young’s modulus) but not for PT. CSA of the AT and PT increased equally in both groups following training. Further, for a given force, stiffness and Young’s modulus also increased equally for VL aponeurosis and AT, for boths groups. The present study highlights that except for the PT, older men have lower tendon (AT, MG aponeurosis, and VL aponeurosis) mechanical properties than young men and 12-weeks of moderate slow resistance training appears sufficient to improve tendon size and mechanical adaptations in both young and older men. New and Noteworthy: These novel findings suggest that short-term moderate slow resistance training induces equal improvements in tendon size and mechanics regardless of age.
... (Phillip, interview) The significance of size and physicality was increased by the differences in size of the young men. Young men continue to grow physically to the age of 21 (Teipel, 2013) and naturally add muscle mass to the age of 30 (Batsis & Buscemi, 2011). Some of the young men entered the prison straight from Woodlands on their 18th birthday and were much smaller and lighter than men of 24 who had been frequenting the gym for several years. ...
Chapter
This chapter considers the communicative elements of masculinity. The prison environment restricts certain conventional means of expressing masculinity, obliging young men to find alternative avenues of masculine communication. The chapter describes how young men used language, hair, physique, shoes, clothes, scars, and other such matters, to do this.
... Diminution des performances avec l'âge(Batsis and Buscemi 2011) ...
Thesis
Un des problèmes majeurs contribuant à la réduction de la mobilité chez la personne âgée est la hausse de l’occurrence des chutes. La capacité à maintenir l’équilibre ou la stabilité posturale a été précédemment associée à la structure et aux propriétés mécaniques des tendons du membre inférieur. Cette étude fut menée afin d’évaluer les effets de l’intensité d’entrainement et de l’âge sur les changements de l’architecture tendineuse et ses propriétés mécaniques ainsi que sur les adaptations musculaires du membre inférieur. Ce projet avait ainsi pour objectif de comparer les effets de deux conditions d’entrainement pour un volume équivalent (intensité modérée (55% d’une répétition maximale (1RM) vs élevée (80% de 1RM)) sur deux groupes musculaires différents (quadriceps vs triceps sural), sur les adaptations des tendons d’Achille et patellaire associés aux adaptations de ces groupes musculaires respectifs. Enfin, le dernier objectif de cette étude était de montrer si des changements de la balance posturale et de la capacité de mouvement pouvaient s’expliquer par les évolutions de l’architecturale et de propriétés mécaniques des structures musculaires et tendineuses avec l’âge. Dix hommes jeunes (Age : 24.8 ± 3.6) et 27 séniors (Age : 69.9 ± 4.5) sédentaires ont été recrutés et ont participé à un programme d’entrainement en résistance de 12 semaines (3 fois/semaine) sur les muscles du triceps sural et du quadriceps. Le groupe de jeunes (n=10) ainsi qu’un groupe de séniors (n=13) ont participé à un programme d’entrainement modéré correspondant à 55% de 1RM, tandis qu’un deuxième groupe de seniors s’est vu imposer une intensité d’entrainement de 80% de 1RM (n=14). Chaque groupe a reçu exactement le même volume d'entraînement sur les muscles quadriceps et triceps sural en utilisant des machines de musculation guidées : la presse à jambes, l'extension des jambes et la machine à mollets assis. Afin de pouvoir obtenir les paramètres nécessaires à cette étude, l’utilisation d’ergomètres, d’images échographiques et IRM et d’un système de capture de mouvement ont été nécessaires. En comparant deux populations de jeunes et de séniors, cette étude a ainsi permis de quantifier une diminution de la force, couplée ou non suivant le tendon considéré à une diminution des propriétés intrinsèques du matériau tendineux. L’obtention de l’architecture musculaire a permis de construire les courbes d’évolutions de la section de chacun des muscles du quadriceps et du triceps sural pour les populations jeunes et séniors. Les deux conditions d’entrainement nous ont permis de mettre en évidence une amélioration des propriétés mécaniques des tendons d’Achille et patellaire, et plus sensiblement le tendon d’Achille, sur les deux populations jeunes et séniors sans toutefois observer de gain supplémentaire pour une intensité élevée. Des gains similaires suite à la période d’entrainement ont pu être observés chez les séniors sur les volumes des muscles du triceps sural et du quadriceps sans distinction de l’intensité considérée. L’analyse du mouvement nous a permis de mettre en évidence l’amélioration de la stabilité posturale et une évolution de la stratégie de flexion du tronc lors d’un lever de chaise suite à l’entrainement chez les séniors sans bénéfice supplémentaire entre une intensité modérée et élevée. De plus, les effets de l’âge sur les propriétés mécaniques des tendons ont pu être corrélés avec les performances liées aux exercices de stabilité posturale, de saut et de lever de chaise. Ce travail a donc permis de quantifier les effets de l’âge sur les capacités musculaires, tendineuses et de mouvement. Cette étude nous a également permis de mettre en évidence un seuil d’intensité d’entrainement (55% de 1RM) à partir duquel les personnes âgées ne semblent pas montrer de gain additionnel pour les systèmes musculaires et tendineux. Ce travail permet donc de proposer une optimisation de l’activité physique prescrite à la personne âgée ou vieillissante.
... 4 Furthermore, it may be underdiagnosed and have multiple causes 5 6 and is also associated with insulin resistance and low-grade inflammation. 7 Exercise, diet and nutritional interventions seem to have a preventive effect on the strengths and limitations of this study ► The study is designed as a randomised controlled trial, and the intervention is placebo controlled and double blinded. ► A strength of this study is the comprehensive data collection, with physical and anthropometric measures related to a thorough assessment of nutritional intake, nutritional status and view on nutrition. ...
... ► A strength of this study is the comprehensive data collection, with physical and anthropometric measures related to a thorough assessment of nutritional intake, nutritional status and view on nutrition. ► The intervention period for this study is [6][7][8][9][10][11][12] months, making the study appropriate for documenting potential preventive effects on age-related loss of muscle function or strength. ► A limitation of this study may be the anthropometric method used to assess muscle mass. ...
Article
Full-text available
Introduction Age-related loss of muscle mass, muscle strength and muscle function (sarcopenia) leads to a decline in physical performance, loss of independence and reduced quality of life. Nutritional supplements may delay the progression of sarcopenia. The aim of this randomised, double-blinded controlled trial including 100 participants (≥65 years) is to assess the effect of a marine protein hydrolysate (MPH) on sarcopenia-related outcomes like hand grip strength, physical performance or gait speed and to study the associations between physical performance and nutritional intake and status. Method and analysis The intervention group (n=50) will receive 3 g of MPH per day in 12 months. The control group (n=50) receive placebo. Assessments of Short Physical Performance Battery (SPPB), hand grip strength, anthropometric measurements, nutritional status as measured by the Mini Nutritional Assessment, dietary intake, supplement use, biomarkers of protein nutrition and vitamin D, and health-related quality of life (EQ-5D), will be performed at baseline and after 6 and 12 months of intervention. Linear mixed models will be estimated to assess the effect of MPH on SPPB, hand grip strength and quality of life, as well as associations between physical performance and nutrition. Ethics and dissemination The study has been approved by the Regional Committee in Ethics in Medical Research in Mid-Norway in September 2016 with the registration ID 2016/1152. The results will be actively disseminated through peer-reviewed journals, conference presentations, social media, broadcast media and print media. Trial registration number NCT02890290 .
Article
Full-text available
Sarcopenia, characterized by loss of muscle mass and strength, is common in advanced old age but can be accelerated by chronic disease, malnutrition and physical inactivity. Early initiation of intervention to achieve and maintain a higher peak muscle mass and strength may allow for prevention or delay of sarcopenia and facilitate independent living even in old age. In this context, malnutrition, a significant contributor to sarcopenia, is often overlooked among the Indian population. Maintenance of an optimal energy and protein balance with adequate physical activity level is essential to preserve physical function in the aging population. However, research on the role of micronutrients in muscle maintenance, is still in its infancy. This narrative review, therefore, aims to explore the current status of International and Indian research on the role of nutrition in sarcopenia mitigation and the way forward.
Chapter
Development is fundamental for living beings. As robots are often designed to mimic biological organisms, development is believed to be crucial for achieving successful results in robotic agents, as well. What is not clear, though, is the most appropriate scheduling for development. While in real life systems development happens mostly during the initial growth phase of organisms, it has not yet been investigated whether such assumption holds also for artificial creatures. In this paper, we employ a evolutionary approach to optimize the development—according to different representations—of Voxel-based Soft Robots (VSRs), a kind of modular robots. In our study, development consists in the addition of new voxels to the VSR, at fixed time instants, depending on the development schedule. We experiment with different schedules and show that, similarly to living organisms, artificial agents benefit from development occurring at early stages of life more than from development lasting for their entire life.KeywordsAdaptationEvolutionary RoboticsEmbodied cognitionDevelopmentBody-brain evolution
Article
Background and aims Sarcopenia leads to metabolic and vascular abnormalities. However, little is known regarding the independent relationship between skeletal muscle mass and atherosclerosis in patients with type 2 diabetes mellitus (T2DM). This study aimed to evaluate the association between skeletal muscle mass and carotid atherosclerosis in men and women with T2DM. Methods In this cross-sectional study, a total of 8202 patients with T2DM were recruited from the Seoul Metabolic Syndrome cohort. Skeletal muscle mass was estimated using bioimpedance analysis, while skeletal muscle mass index (SMI, %) was defined as total skeletal muscle mass (kg)/body weight (kg) × 100. Both carotid arteries were examined by B-mode ultrasound. Carotid atherosclerosis was defined by having a carotid plaque or mean carotid intima-media thickness (IMT) ≥1.1 mm. Results Among the entire population, 4299 (52.4%) subjects had carotid atherosclerosis. The prevalence of carotid atherosclerosis increased with decreasing SMI quartiles for both sexes. The odds ratios for carotid atherosclerosis were 2.33 (95% confidence interval [CI], 1.17-4.63) and 2.24 (95% CI, 1.06-4.741) in the lowest versus highest SMI quartile in men and women, respectively, after the adjustment for clinical risk factors. In men, the risk of atherosclerosis increased linearly with decreasing SMI quartiles (p for trend = 0.036). Conclusions Low skeletal muscle mass was independently associated with the presence of carotid atherosclerosis in men and women with T2DM.
Chapter
Oxidative stress has been related to osteoporosis and other pathologies at the bone. Coenzyme Q10 (CoQ10), a lipid-soluble antioxidant present in cell membranes, has been suggested in vitro to reduce intracellular reactive oxygen species (ROS) production at the same time to prevent or reduce osteoclastogenesis. Also, it promotes osteoblast differentiation and proliferation and matrix mineralization. Thus it has been suggested that this effect on osteoclastogenesis could be a consequence of the reduction of intracellular ROS. The protective effect of CoQ10 against bone loss has been also demonstrated in rodents. Age-associated changes in systemic markers of oxidative damage in animals treated with CoQ10 suggest that this antioxidant can reduce not only intracellular ROS alleviating oxidative damage but also osteoclastogenesis and bone resorption triggered by different signals. Additionally, it has been suggested that oxidative stress is the main mechanism explaining bone alterations both in aged rodents and in those with acute sex steroid deficiency.
Article
Full-text available
Objective: Patients with type 2 diabetes mellitus (T2DM) are subject to progressive reduction of muscle strength especially in the lower limb. But the rate of progression of weakness is not clear yet. The aim of the study was to compare the isometric and concentric peak torque of knee extension and flexion in the T2DM more and less than 10 years of disease with healthy subjects that matched to patients with regards to sex, body mass index (BMI), ankle to brachial pressure index (ABI), and physical activity index (PAI). Materials and Methods: 30 T2DM patients categorized based on duration of disease in the two groups consist of 18 subjects with T2DM less than 10 years and 12 subjects with T2DM more than 10 years. The patients were compared with 20 sex, BMI, ABI and PAI - matched health subjects. Two- way ANCOVA analyzed the main and interaction effect of grouping and sex on the isometric maximum peak torque (IMPT) and concentric MPT (CMPT) of knee extension and flexion recorded by isokinetic instrument. The age was considered as covariate. Results: The results showed that both knee extensor and flexor IMPT and CMPT were significantly greater in the health subjects than both patient groups (P value<0.02). The amount of CMPT had also negative correlation with HbA1c percent (P value < 0.002). There was no significant interaction effect of sex and grouping and different between two diabetic groups in the all MPTs. the women were weaker than men (P value < 0.002). Conclusion: it is demonstrated that the T2DM patients in the both sexes had less knee strength than health subjects. The effect of duration of diabetes on muscle strength was seem very slowly overtime.