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Mucosal atrophy and ulcers.

Mucosal atrophy and ulcers.

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Figure 1. Mucosal atrophy and ulcers.
Figure 2. Deposition of amyloid A in colon tissue.
Secondary Amyloidosis Treated with Tocilizumab as a Complication of Temporal Arteritis
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  • Oct 2024
Background Temporal arteritis is a large-vessel vasculitis mostly seen in the elderly. Amyloidosis may be secondary to a chronic inflammation of body organs. Here, we present the second case report of temporal arteritis complicated by amyloidosis that was successfully treated by tocilizumab. Case presentation A 64-year-old female presented complai...
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... quickly improved, and inflammatory marker levels decreased. However, the diarrhea persisted. Lower gastrointestinal (GI) endoscopy was performed due to the persistence of diarrhea. Endoscopy showed chronic colitis with ulcers and mucosal atrophy (Fig. 1). Histopathology of the colon tissue confirmed amyloid deposition in the stroma and vessels, shown as a pink amorphous material positive for Congo red staining (Fig. 2), in addition to distorted crypt architecture with chronic colitis, and heavy infiltration of lymph-plasma cells. Circulating levels of SAA were 31.7 mg/ dl (normal ...