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Modulating potential of OECG on the antibiotic activity of amoxicillin against strains SA 10-S. aureus 10; EC 06-E. coli 06; KP BLSE-K. pneumoniae BLSE; KPC-K. pneumoniae Carbapenemáse; KP ICU-K. pneumoniae clinical urine isolate; SA 29213-S. aureus ATCC 29213; EC 25922-E. coli ATCC 25922. Source: author. Two-way ANOVA followed by Bonferroni post-test, using GraphPad Prism 10.0 software. **** p < 0.0001.
Source publication
Background: Croton grewioides Baill., a species native to the Caatinga, popularly known as canela de cunhã, is used in traditional medicine to treat gastrointestinal diseases such as diarrhea, gastritis and stomach ulcers. The combination of essential oils with antibiotics reveals several beneficial effects associated with the increased efficacy of...
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Context 1
... effect of OECG against aminoglycoside antibiotics showed that amikacin ( Figure 5) presented synergistic effects in all strains tested except K. pneumoniae (BLSE), which presented an antagonistic effect, and K. pneumoniae (KPC), which demonstrated equivalence to the control. As for gentamicin (Figure 6), synergistic effects were observed in all strains tested, except for K. pneumoniae (KPC), which exhibited an antagonistic effect. ...
Context 2
... effect of OECG against aminoglycoside antibiotics showed that amikacin ( Figure 5) presented synergistic effects in all strains tested except K. pneumoniae (BLSE), which presented an antagonistic effect, and K. pneumoniae (KPC), which demonstrated equivalence to the control. As for gentamicin (Figure 6), synergistic effects were observed in all strains tested, except for K. pneumoniae (KPC), which exhibited an antagonistic effect. Protein synthesis inhibitors that act on bacterial ribosomes in the 30S and 50S subunits are mainly classified as aminoglycosides, tetracyclines, and aphenicols, among others. ...
Context 3
... effect of OECG against aminoglycoside antibiotics showed that amikacin ( Figure 5) presented synergistic effects in all strains tested except K. pneumoniae (BLSE), which presented an antagonistic effect, and K. pneumoniae (KPC), which demonstrated equivalence to the control. As for gentamicin (Figure 6), synergistic effects were observed in all strains tested, except for K. pneumoniae (KPC), which exhibited an antagonistic effect. Protein synthesis inhibitors that act on bacterial ribosomes in the 30S and 50S subunits are mainly classified as aminoglycosides, tetracyclines, and aphenicols, among others. ...
Similar publications
Croton grewioides Baill., a species native to the Caatinga, popularly known as canela de cunhã, is used in traditional medicine to treat gastrointestinal diseases such as diarrhea, gastritis and stomach ulcers. This study aimed to identify the chemical composition of the essential oil of C. grewioides (OECG) and evaluate its antibacterial and antib...
Citations
Cancer is a group of diseases characterized by uncontrolled cell growth, invasive capacity, and metastatic potential. Despite the continual progress in cancer treatment, high toxicity and resistance to therapy remain recurring challenges. Croton grewioides Baill. is a plant from the brazilian semi‐arid region with significant pharmacological potential due to its reported antidiarrheal, antioxidant, and antitumor properties. This study evaluated the antitumor activity of the essential oil from C. grewioides leaves (CgEO) by in vitro assays. CgEO showed higher cytotoxicity in human melanoma cells (SK‐MEL‐28), with a 50% inhibitory concentration (IC50) of 70.0 μg/mL after 72 hours, but with low toxicity in healthy keratinocytes (HaCaT). Additionally, it was suggested that the antitumor effect of CgEO is associated with the induction of apoptosis, cell cycle alterations, and combined antioxidant action mechanisms. In conclusion, CgEO exhibits antitumor activity with lower toxicity in non‐tumor cells.
