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Fig 8 - Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium

Fig. 8 Model of cell type-specific regulation of ERK activity. ERK is regulated cell type-specific and cell-intrinsic via different strengths of feedback inhibition and feed-forward signalling from MEK to ERK. Dual-specificity phosphatases (DUSPs) are important regulators of ERK activity. β-catenin and KRAS G12V activities modulate cell fate decisions towards the generation of cells with high ERK activity, likely in part due to low expression of genes encoding DUSPs
Model of cell type-specific regulation of ERK activity. ERK is regulated cell type-specific and cell-intrinsic via different strengths of feedback inhibition and feed-forward signalling from MEK to ERK. Dual-specificity phosphatases (DUSPs) are important regulators of ERK activity. β-catenin and KRAS G12V activities modulate cell fate decisions towards the generation of cells with high ERK activity, likely in part due to low expression of genes encoding DUSPs
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