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Model of Protein alteration during S. haematobium infections afflicted to host pathology (Osakunor et al., 2022).
Source publication
Schistosomiasis, or Bilharziasis, is a neglected tropical disease caused by Schistosoma parasites, which significantly impacts public health, particularly in Africa. Schistosoma haematobium, the primary species responsible for urogenital schistosomiasis (UGS), is associated with severe chronic conditions, including squamous cell carcinoma (SCC) of...
Context in source publication
Context 1
... a deeper understanding of the mechanisms involved in immunomodulation during chronic schistosomiasis and UGS-related carcinogenesis will offer new perspectives for optimizing schistosomiasis treatment strategies and preventing or treating UGS-related bladder cancer. Proteomic alterations contribute to the complex dynamics of urothelial pathology and characteristic bladder tissue changes in urogenital schistosomiasis (Figure 3). This model demonstrates how the differential expression of the observed proteins contributes to notable pathology including, urothelial hyperplasia, carcinogenesis, active protein translation and enhanced immune and inflammatory responses relevant for wound healing and granuloma formation, induction of Th2 immune responses, reduced structural integrity important for egg shedding, all of which are characteristic of Schistosoma infection ). ...
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