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Metabolites identified in urine with UGS and UGSassociated SCC that were not present in the urine of healthy individuals (Santos et al., 2021). The metabolites were divided into three groups: catechol-oestrogen-like (green), catechol-oestrogen-DNA adducts (red), and 8-oxodG derivatives (blue). The catechol oestrogen-DNA adducts may result from the interaction of catechol oestrogen derivatives with host DNA. On the other hand, 8-oxodG derivatives may be a result of the liberation of nitrogenous bases from DNA and/or its oxidation.
Source publication
Schistosomiasis, or Bilharziasis, is a neglected tropical disease caused by Schistosoma parasites, which significantly impacts public health, particularly in Africa. Schistosoma haematobium, the primary species responsible for urogenital schistosomiasis (UGS), is associated with severe chronic conditions, including squamous cell carcinoma (SCC) of...
Context in source publication
Context 1
... these compounds provides insights into the fundamental pathophysiology of cancer associated with the infection and presents potential translational opportunities, such as identifying the molecules as potential biomarkers. The molecules originating from 8-oxodG or oestrogen derivatives ( Figure 5) could potentially serve as urine biomarkers for the early detection and progression of bladder cancer, as stated by Santos et al. (2021). 8-oxodG is a representative indicator of DNA oxidative damage during oxidative stress. ...
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