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Mast cell populations in the gut. Gut sections from sensitized mice treated with IL-2/JES6 or PBS for three days prior to sensitization. Mast cells were identified by chloroacetate esterase (CAE) staining. (A) Representative section of duodenum, 40x magnification. (B) All mast cells, connective tissue mast cells and mucosal mast cells in jejunum (upper row) and duodenum (lower row) are shown, as indicated. Plots show mast cells per field of view (MC/field). Upper row: jejunum, lower row: duodenum, as indicated. Each dot represents the average mast cell counts from one individual mouse, two to six slices were counted per mouse (n = 5; Mann-Whitney U test). ns, not significant.

Mast cell populations in the gut. Gut sections from sensitized mice treated with IL-2/JES6 or PBS for three days prior to sensitization. Mast cells were identified by chloroacetate esterase (CAE) staining. (A) Representative section of duodenum, 40x magnification. (B) All mast cells, connective tissue mast cells and mucosal mast cells in jejunum (upper row) and duodenum (lower row) are shown, as indicated. Plots show mast cells per field of view (MC/field). Upper row: jejunum, lower row: duodenum, as indicated. Each dot represents the average mast cell counts from one individual mouse, two to six slices were counted per mouse (n = 5; Mann-Whitney U test). ns, not significant.

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... Contrastingly, Th1 reaction and the prototypic cytokine interferon (IFN)-γ could counterbalance Th2 responses, thus reducing the generation of IL-4 and IgE and ultimately inhibiting allergic sensitization. 13 Regulating Th1/Th2 balance exerts certain roles in mitigating allergic inflammatory responses in ovalbumin-elicited AR mice. 14 From the aforementioned research, we can learn the paramount significance of the Th1/Th2 balance in AR. ...
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