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Ethnobotanical survey in the Magar villages in Nawalpur district, Gandaki province, Nepal revealed that root of Phanera vahlii (Wight & Arn.) Benth, bark of Rhododendron arboreum Sm. and flower of Woodfordia fruticosa (L.) Kurz, have been in use for diarrhea and dysentery. Root of Thalictrum foliolosum DC. has been used for the treatment of rheumat...
Citations
... DPPH • solution (0.1 mM) was prepared by overnight stirring of DPPH (3.9 mg) in HPLC grade methanol (100 mL) (Brand-Williams et al., 1995;Nemkul et al., 2021;Nemkul et al., 2022). The methanolic solutions of Gallic acid standard and chalcones (50 μL) were loaded in 96 well plates in triplicates, and then DPPH • radical solution (250 μL) was added. ...
Depletion of dietary antioxidants has been related to rising of oxidative stress that causes chronic and degenerative diseases such as cancers, Alzheimer and aging. Therefore, finding of a readily available antioxidant is essential to offer potential chemotherapeutics. In this study, (E)-1,3-diphenylprop-2-en-1-one (1), (E)-1-(3-nitrophenyl)-3-phenylprop-2-en-1-one (2), (E)-3-(furan-2-yl)-1-(3-nitropheyl)prop-2-en-1-one (3), (E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one (4), (E)-3-(furan-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one (5), (E)-1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (6) and (E)-3-(4-(dimethylamino)phenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (7), that readily obtained through the Crossed-Aldol condensation between arylmethyl ketones and aromatic aldehydes, were evaluated for the antioxidant activity by using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2′-Azinobis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and Nitric oxide (NO) assays. Among the chalcones investigated, compound 7 has displayed antioxidant activity in the ABTS assay with IC50 value of 464 μM (calcd. 124 µg/mL) indicating a para-dimethylamino substitution in the B ring of chalcone enhances reduction of cationic free radical ABTS•+.
