Local genetic correlations between neuropsychiatric and insulin resistance-related conditions a Chord diagram representing the network of local genetic correlations between insulin resistance-related conditions and neuropsychiatric disorders. A higher width of a ribbon reflects a higher number of shared genetically correlated loci between two phenotypes, highlighting a substantial polygenic overlap and suggesting potential shared pathophysiological mechanisms between them. The colours of the ribbons are used purely for visual distinction and do not imply any additional significance or categorisation. Labels for insulin resistance–related conditions are displayed in dark cyan, while those for neuropsychiatric disorders are shown in black. b Bar plot presenting the number of local genetic correlations identified between neuropsychiatric disorders and insulin resistance-related conditions. Each bar corresponds to a different neuropsychiatric disorder, segmented by the direction of effect of local genetic correlations, with blue indicating negative and red indicating positive local genetic correlations between neuropsychiatric disorders and insulin resistance-related conditions. The height of each bar reflects the quantity of local genetic correlations detected for each disorder. c Network visualisation of local genetic correlations between a spectrum of neuropsychiatric disorders and insulin resistance-related conditions. Nodes represent distinct phenotypes for which local bivariate genetic correlations were evaluated; nodes for insulin resistance–related conditions are labeled in dark cyan, while those for neuropsychiatric disorders are labeled in black. Edges connecting the nodes vary in width proportionally to the number of local genetic correlations identified between phenotype pairs. Edge colour denotes the direction of the genetic correlation estimate, with red indicating a positive correlation and blue indicating a negative correlation. Abbreviations: AD, Alzheimer’s disease; ADHD, attention-deficit/hyperactivity disorder; AN, anorexia nervosa; ASD, autism spectrum disorder; BD, bipolar disorder; MDD, major depressive disorder; MetS, metabolic syndrome, OCD, obsessive-compulsive disorder; T2DM, type 2 diabetes mellitus; SCZ, schizophrenia; TS, Tourette’s syndrome.