Figure - available from: Medical Oncology
This content is subject to copyright. Terms and conditions apply.
LncRNAs targeting pathways; MAPK/ERK, EGFR, TGF-β axis, PTEN/AKT/PI3K, PI3K/AKT/mTOR, Wnt/β-catenin, HH, KRAS routs, NF-kB, HH, p53, and HIF-1α in GC

LncRNAs targeting pathways; MAPK/ERK, EGFR, TGF-β axis, PTEN/AKT/PI3K, PI3K/AKT/mTOR, Wnt/β-catenin, HH, KRAS routs, NF-kB, HH, p53, and HIF-1α in GC

Source publication
Article
Full-text available
Gastric cancers (GCs) are among the most common and fatal malignancies in the world. Despite our increasing understanding of the molecular mechanisms underlying GC, further biomarkers are still needed for more in-depth examination, focused prognosis, and treatment. GC is one among the long non-coding RNAs, or lncRNAs, that have emerged as key regul...

Similar publications

Preprint
Full-text available
Question-asking in collaborative dialogue has long been established as key to knowledge construction, both in internal and collaborative problem solving. In this work, we examine probing questions in collaborative dialogues: questions that explicitly elicit responses from the speaker's interlocutors. Specifically, we focus on modeling the causal re...
Article
Full-text available
During the 2022 Sinop Balatlar Excavation, a pebble stone mosaic floor was unearthed. The design of the mosaic, which adorns the andron room of a private residence, is U-shaped and the east-west kline sections are planned without decoration. The pebble floor placed horizontally and vertically on a pink nucleus is called the “hedgehog” model. Surrou...
Article
Full-text available
Cancer remains a significant global challenge, and despite the numerous strategies developed to advance cancer therapy, an effective cure for metastatic cancer remains elusive. A major hurdle in treatment success is the ability of cancer cells, particularly cancer stem cells (CSCs), to resist therapy. These CSCs possess unique abilities, including...
Article
Full-text available
Melanoma is a highly malignant skin tumor characterized by high metastasis and poor prognosis. Recent studies have highlighted the pivotal role of melanoma stem cells (MSCs)—a subpopulation of cancer stem cells (CSCs)—in driving tumor growth, metastasis, therapeutic resistance, and recurrence. Similar to CSCs in other cancers, MSCs possess unique c...
Article
Full-text available
Background/Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is increasing throughout the world. Nevertheless, no specific diagnostic or even risk assessment marker is available. Combining more than one marker can improve the diagnostic value of each marker alone and maximize the AUC for ROC curve. Hedgehog (Hh) signa...

Citations

... Similarly, lncRNA also plays an important role in the development of GC. LncRNA affects GC-related carcinogenic signaling cascades including pathways for PI3K/AKT/mTOR, p53, Wnt/b-catenin, JAK/STAT, and others (13). Moreover, Li et al. report that H19 may regulate the immune cell infiltration in carcinogenesis of GC through miR-378a-5p/SERPINH1 signaling, such as B cells, CD4+ T cells (14). ...
Article
Full-text available
Background Long non-coding RNAs (lncRNAs) in extracellular vesicles (EVs) have been confirmed as effective non-invasive biomarkers for multiple diseases. However, their expression and clinical value in gastric cancer (GC) remain poorly understood. Materials and methods Serum EV RNA was extracted from four patients with GC and four healthy controls, followed by high-throughput RNA sequencing. LncRNAs were further validated in training and validation sets using quantitative real-time reverse transcription polymerase chain reaction. Results A total of 37,684 lncRNAs were obtained, and 10 lncRNAs were selected based on the criteria (P < 0.05 and |log2FoldChange| ≥1). Serum EV lncRNA RMRP, RPPH1, and linc-ROR were significantly higher in patients with GC than in those with chronic gastritis, atypical hyperplasia, or healthy control (all P < 0.05). Three lncRNAs were also significantly correlated with tumor diameter, lymphatic metastasis, distal metastasis, and TNM stage (all P < 0.05). The area under the curve (AUC) values for lncRNA RMRP, RPPH1, and linc-ROR were 0.727, 0.774, and 0.811, respectively. Corresponding sensitivity and specificity were 63.4% and 85.4%, 50.7% and 89.6%, and 78.5% and 66.7%. The combination of these three lncRNAs with carcinoembryonic antigen (CEA) yielded an AUC of 0.909, with a sensitivity and specificity of 83.3% each. Furthermore, high EV linc-ROR and RMRP expression levels were associated with worse disease-free survival and overall survival (OS). Univariate and multivariate Cox regression analyses confirmed that linc-ROR was the only independent prognostic factor for GC. Finally, the lncRNA-miRNA-mRNA network showed that three lncRNAs were predicted to interact with 15 miRNAs and 69 mRNAs. In addition, lncRNA RMRP and linc-ROR were correlated with immune cell infiltration, including neutrophils, central memory CD4 T cells, macrophage, and natural kill T cells. Conclusion EV lncRNAs are prospective biomarker and correlated with immune cell infiltration in GC. It provides a foundation for the development of serum EV-targeted novel biomarkers and immunotherapy targets of GC.
... Central to this pathway is PTEN (phosphatase and tensin homolog), a tumor suppressor gene located on chromosome 10. PTEN functions by dephosphorylating phosphatidylinositol-3,4,5-trisphosphate (PIP3), thereby reducing PIP3 levels (Mighell et al. 2018;Elimam et al. 2024a). This reduction inhibits the PI3K signaling pathway and its downstream effectors, particularly Akt/mTOR, which are crucial for cancer progression. ...
Article
Full-text available
Prostate cancer (PC) ranks among the most prevalent cancers in males. Recent studies have highlighted intricate connections between long non-coding RNAs (lncRNAs), natural products, and cellular signaling in PC development. LncRNAs, which are RNA transcripts without protein-coding function, influence cell growth, programmed cell death, metastasis, and resistance to treatments through pathways like PI3K/AKT, WNT/β-catenin, and androgen receptor signaling. Certain lncRNAs, including HOTAIR and PCA3, are associated with PC progression, with potential as diagnostic markers. Natural compounds, such as curcumin and resveratrol, demonstrate anticancer effects by targeting these pathways, reducing tumor growth, and modulating lncRNA expression. For instance, curcumin suppresses HOTAIR levels, hindering PC cell proliferation and invasion. The interaction between lncRNAs and natural compounds may open new avenues for therapy, as these substances can simultaneously impact multiple signaling pathways. These complex interactions offer promising directions for developing innovative PC treatments, enhancing diagnostics, and identifying new biomarkers for improved prevention and targeted therapy. This review aims to map the multifaceted relationship among natural products, lncRNAs, and signaling pathways in PC pathogenesis, focusing on key pathways such as AR, PI3K/AKT/mTOR, WNT/β-catenin, and MAPK, which are crucial in PC progression and therapy resistance. Regulation of these pathways by natural products and lncRNAs could lead to new insights into biomarker identification, preventive measures, and targeted PC therapies.
... Numerous research has looked into their roles in the initiation and spread of cancer. Numerous facets of non-coding RNAs have been investigated in these investigations, such as their modes of action, genomic features, biogenesis, functional phenotypes in experimental models, and involvement in cellular pathways (Elimam et al. 2024a). ...
... LncRNAs are a class of transcripts longer than two hundred nucleotides that do not code for proteins. They become critical modulators of cellular processes and gene expression (Elazazy et al. 2023;Elimam et al. 2024a). Their potential to interact in interactions with proteins, DNA, and other RNA molecules allows them to manipulate complicated signaling cascades, which in turn influences the fate and conduct of individual cells. ...
... The Transforming Growth Factor-beta (TGF-β) pathway is renowned for its versatility in biological situations. It elicits a broad spectrum of responses, including the orchestration of embryonic tissue development, morphogenesis, and the induction of cytostatic and apoptotic mechanisms in epithelial cells (Baba et al. 2022;Doghish et al. 2024a). Thus, the role of TGF-β signaling in cancer is multifaceted and intricate (Baba et al. 2022). ...
Article
Full-text available
Glioblastoma (GBM) is one of the most aggressive types of brain cancer, characterized by its poor prognosis and low survival rate despite current treatment modalities. Because GBM is lethal, clarifying the pathogenesis’s underlying mechanisms is important, which are still poorly understood. Recent discoveries in the fields of molecular genetics and cancer biology have demonstrated the critical role that non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs), play in the molecular pathophysiology of GBM growth. LncRNAs are transcripts longer than 200 nucleotides that do not encode proteins. They are significant epigenetic modulators that control gene e expression at several levels. Their dysregulation and interactions with important signaling pathways play a major role in the malignancy and development of GBM. The increasing role of lncRNAs in GBM pathogenesis is thoroughly examined in this review, with particular attention given to their regulation mechanisms in key signaling pathways such as PI3K/AKT, Wnt/β-catenin, and p53. It also looks into lncRNAs’ potential as new biomarkers and treatment targets for GBM. In addition, the study discusses the difficulties in delivering lncRNA-based medicines across the blood-brain barrier and identifies areas that need more research to advance lncRNA-oriented treatments for this deadly cancer. Graphical abstract
... Various lncRNAs have been classified according to their genomic position: sense lncRNA, antisense lncRNA, intronic lncRNA, and intergenic lncRNA (Ma et al. 2013). They can regulate the expression of coding genes by different mechanisms: epigenetic regulation, chromatin remodeling, and regulation of transcription factors (Aprile et al. 2020;Elimam et al. 2024a). ...
Article
Full-text available
Colorectal cancer (CRC) is recognized as one of the most prevalent malignancies, both in terms of incidence and mortality rates. Current research into CRC has shed light on the molecular mechanisms driving its development. Several factors, including lifestyle, environmental influences, genetics, and diet, play significant roles in its pathogenesis. Natural compounds such as curcumin, tanshinone, lycorine, sinomenine, kaempferol, verbascoside, quercetin, berberine, and fisetin have shown great promise in the prevention and treatment of CRC. Research has also highlighted the significance of non-coding RNAs (ncRNAs) as biomarkers and therapeutic targets in CRC. Among these, long non-coding RNAs (lncRNAs) have been found to regulate the transcription of genes involved in cancer. LncRNAs contribute to cancer stem cell (CSC) proliferation, angiogenesis, epithelial-mesenchymal transition (EMT), and chemoresistance. Specific lncRNAs, including GAS5, LNC00337, HOTAIR, TPT1-AS1, cCSC1, BCAR4, TUG1, and Solh2, play crucial roles in these processes. They hold potential as novel biomarkers, detectable in bodily fluids and tissues, and could serve as therapeutic targets due to their involvement in drug resistance and sensitivity. These insights could improve CRC treatment strategies, addressing resistance to chemotherapy and radiotherapy. This review article aims to provide a comprehensive analysis of the current knowledge regarding the effectiveness of natural anti-cancer agents in CRC treatment. Additionally, it offers an in-depth evaluation of lncRNAs in CRC, their role in the disease’s progression, and their potential applications in its management. Graphical Abstract
Article
Full-text available
Gastric cancer (GC) remains a major public health challenge worldwide. Long non-coding RNAs (lncRNAs) play important roles in the development, progression, and resistance to the treatment of GC, as shown by recent developments in molecular characterization. Still, an in-depth investigation of the lncRNA landscape in GC is absent. However, The objective of this systematic review is to evaluate our present understanding of the role that lncRNA dysregulation plays in the etiology of GC and treatment resistance, with a focus on the underlying mechanisms and clinical implications. Research that described the functions of lncRNA in angiogenesis, stemness, epigenetics, metastasis, apoptosis, development, and resistance to key treatments was given priority. In GC, it has been discovered that a large number of lncRNAs, including MALAT1, HOTAIR, H19, and ANRIL, are aberrantly expressed and are connected with disease-related outcomes. Through various methods such as chromatin remodeling, signal transduction pathways, and microRNA sponging, they modulate hallmark cancer capabilities. Through the activation of stemness programs, epithelial-mesenchymal transition (EMT), and survival signaling, LncRNAs also control resistance to immunotherapy, chemotherapy, and targeted therapies. By clarifying their molecular roles further, we may be able to identify new treatment targets and ways to overcome resistance. This article aims to explore the interplay between lncRNAs, and GC. Specifically, the focus is on understanding how lncRNAs contribute to the etiology of GC and influence treatment resistance in patients with this disease.