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Left column (A, B: Limbal-conjunctival autograft without 0.02% MMC, C, D: Limbal-conjunctival autograft with 0.02% MMC) Images of preoperative fleshy grade 3 nasal primary pterygium. Right column (E, F: Limbal- conjunctival autograft without 0.02% MMC, G, H: Limbal-conjunctival autograft with 0.02% MMC) Images of the LCAT of the same patients 6 months after the surgery. Well-positioned graft and reestablishment of the normal limbal architecture are observed with no signs of recurrences in all subjects. Notice: The lack of scar on the donor and recipient conjunctiva due to the use of bioadhesives, and the cosmetic advantage due to appropriate size of conjuctival flap after extensive pterygium excision are apparent. 

Left column (A, B: Limbal-conjunctival autograft without 0.02% MMC, C, D: Limbal-conjunctival autograft with 0.02% MMC) Images of preoperative fleshy grade 3 nasal primary pterygium. Right column (E, F: Limbal- conjunctival autograft without 0.02% MMC, G, H: Limbal-conjunctival autograft with 0.02% MMC) Images of the LCAT of the same patients 6 months after the surgery. Well-positioned graft and reestablishment of the normal limbal architecture are observed with no signs of recurrences in all subjects. Notice: The lack of scar on the donor and recipient conjunctiva due to the use of bioadhesives, and the cosmetic advantage due to appropriate size of conjuctival flap after extensive pterygium excision are apparent. 

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To evaluate the effectiveness of Mitomycin C used as a combined therapy along with limbal-conjunctival autograft for primary pterygium.

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Purpose: We evaluated a combination of intraoperative mitomycin C (MMC) and amniotic membrane transplantation (AMT) for treating recurrent pterygia. Methods: We retrospectively analyzed 40 eyes of 39 patients with recurrent pterygia who underwent AMT from December 2007 to July 2015 and who were followed-up for a minimum of 12 months. In all, 22 eyes received intraoperative MMC (group A) and 18 did not (group B). Recurrence rates and complications were compared between the two groups. Results: Conjunctival recurrence was noted in two and corneal recurrence was noted in four eyes of group A (27.3%); the figures for group B were four and three (38.9%). These recurrence rates were not significantly different (p = 0.545). In five cases with preoperative symblepharon, this condition recurred when MMC was not used (two eyes) but not when MMC was used (three eyes). No major complications such as necrotizing scleritis, scleromalacia, or corneal ulcer were observed in either group after surgery. Conclusions: Intraoperative adjunct MMC therapy did not significantly inhibit recurrence after AMT for treating recurrent pterygia but may reduce the recurrence rate of symblepharon. 2018 The Korean Ophthalmological Society.
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