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Cervical spondylosis or Manyagata Vata is one of the most common diseases arising from change in life style, increased t ravelling on vehicles, continuous sitting and working on computers. Various single and compound herbal and herbo - mineral preparations are mentioned in Ayurved texts for management of cervical spondylosis. In this open randomize...
Context in source publication
Context 1
... 0 Occasional pain only on excessive work (> 8h) or heavy work 1 Intermittent pain felt after 5-6 h of work for slight excessive work 2 Continuous pain of high intensity felt after 1-2 h of light work 3 Severe pain felt continuously, unable to do work for even ½ h 4 Absent 0 Occasional pain felt on carrying extra weight in hands or on shoulders etc. 1 Pain felt intermittently while carrying slightly extra weight in hands or on shoulders etc. 2 Pain felt immediately on carrying even normal weight that is bag etc. in the hand or on shoulders 3 ...
Citations
... (21) Trayodashanga guggulu: It helps in lordosis, sciatica, lumbar spondylosis, promotes strength of bones and joints, an excellent Anti-inflamatory and Analgesic medicine. (11) Panchamrit loha guggulu: It contains Roupya (Silver) and Abhraka (Mica) bhasma an excellent vata shamak, majja Vardhaka rasayana. Useful in (cervical spondylosis), Manyastambha, Majja kshaya symptoms. ...
Background: People's modern lives are mostly dependent on and hooked to digital lifestyles due to the nature of their jobs prolong sitting works for hours in one spot can lead to cervical issues, such as cervical spondylosis. This degenerative condition is persistent age-related wear and tear on the cervical spine's disc and vertebrae is known as cervical spondylosis. In Ayurveda cervical spondylosis can be corelated to the Manyastambha which is one among the 80 types of vata vyadhi. Aim and Objective: To study the effect of Greeva basti (localised cervical oil pooling therapy) and Kukutanda pinda sweda (hens’ egg bolus fomentation) along with Internal medication in the management of Manyastambha. Materials and methods: A 29-year-old female patient came with complaints of pain and stiffness in the back of neck region and mild radiating pain to left shoulder. Patient had complaints since three years and increased since six months used many medications but didn’t get any relief. X-ray finding shows Disc space narrowing at C4-C5, C5-C6 and Straightening of cervical Lordosis due to paraspinal muscle spasm. According to Ayurveda the treatment of vata vyadhi is snehan (oleation) and swedan (Fomentation). So, the treatment like Greeva basti and Kuktanda pinda (hen’s egg bolus) sweda are advised for nine days and followed by Ayurvedic internal medicines for one month. Result: The patient was assessed with subjective and objective parameter before and after treatment. The score of pain reduced from 3 to 0, stiffness from 2 to 0, range of neck movements Flexion from 3 to 0, extension from 3 to 1, lateral flexion rt and lt from 2 to 0, rotation of neck from rt and lt 2 to 0. Conclusion: A treatment protocol, consisting of Greeva basti (localized oil pooling therapy) and Kukutanda pinda sweda (hens’ egg bolus fomentation), and oral herbal medications, significantly improved cervical spondylosis symptoms by 90% and enhanced cervical curvature, as confirmed by radiographic evidence.
... Scientific studies on the formulation containing guggulu reported to have beneficial effect in arthritis and other joint diseases (Patel & Pundarikakshudu, 2016). Clinical study showed that TG is effective in treating patients with cervical spondylosis (Rathod & Sawant, 2013). However, no scientific study has been reported to evaluate anti-arthritic activity of this formulation in experimental animal models. ...
Background
Rheumatoid arthritis is a chronic autoimmune disease affecting millions of people across the world. Trayodashang guggulu (TG) is a classical Ayurvedic formulation used for the treating joint diseases since decades in the Indian system of traditional medicine. The aim of the study was to evaluate anti-arthritic activity of TG against complete Freund’s adjuvant-induced arthritis in Wistar rats.
Methods
Arthritis was induced by single injection of 0.1 ml complete Freund’s adjuvant into the intraplanter surface of left hind paw of Wistar rats. TG was administered orally at the doses of 100, 200, 400 and 800 mg/kg body weight for 14 days. In the preventive dose group, TG was administered at the dose of 100 mg/kg body weight, orally for 28 days. Paw swelling, joint circumference, serum rheumatoid factor, C-reactive protein, serum IL-1 β , TNF- α and histopathological parameters were assessed for the evaluation of arthritis. Effects of TG were compared with standard allopathic drug ibuprofen.
Results
TG reversed complete Freund’s adjuvant-induced arthritis in rats when used for 14 and 28 days. Serum rheumatoid factor, C-reactive protein, IL-1 β and TNF- α were decreased in rats treated with both standard drug ibuprofen and TG.
Conclusion
Oral administration of TG reduced experimentally induced rheumatoid arthritis in rats by reversing elevated level of serum biochemical markers as well as reducing joint destruction similar to ibuprofen. Results obtained from the study paved the way in exploring more specific mechanisms of action of TG involving in vitro and in silico models.
... Analgesic, [80] anti-inflammatory & anti-oxidant activity, [81] anti-arthritic activity [82] , immunomodulatory effect [83] , diuretic [84] , absorption enhancer [85] DISCUSSION Probable Mode of Action of Trayodaśāṇga a Guggulu [86] Trayodaśāṇga, a Guggul is an Ayurvedic formulation of 13 herbs, including Guggulu, that has been prepared in ghee. Constituents such as Śatāvari, Ashwagandha, and Gudūcī are rejuvenators that strengthen Dhatus. ...
Sandhigatavāta is comparable to osteoarthritis of modern medicine. It is a kind of articular degenerative disorders that can affect any joints but generally observed weight bearing joints. It is prevalent since antiquity and commonly exists among elderly age group. Osteoarthritis is the second most common rheumatologic problem and it is the most frequent joint disease with a prevalence of 22% to 39% in India. It is predominant in females as compared to male. Variety of herbal and herbo-mineral formulations are mentioned in Ayurvedic lexicons for its management, Trayodaśāṇga guggulu is one of them. In this concern, we have laid down an emphasis in brief on Sandhigatavaāta and trying to explore the classical and contemporary pharmacological aspects of Trayodaśāṇga guggulu for its management.
... In apabahuk vataprakopa, dhatukshinata, dhatu rukshata, parushata, asthidhatukshaya normally founds. The contents of trayodashang guggulu have been particularly guru, snigdha gunatmak, madhur rasa, madhur vipaki and ushna viryatmak in its properties (9), which corrects the above-referred to signs and symptoms. ...
Background: Apabahuk is disease considered under vatavaydhi which can be compared with frozen shoulder considering similarity of signs and symptoms of disease. It is estimated that Between 16-26% of shoulder pain cases are self-reported. It's the third commonest explanation for musculoskeletal consultation in medical care. Severely restricted movements of shoulder joint and progressive loss of both active and passive range of movements are the characteristics of frozen shoulder. In modern medicine several anti-inflammatory analgesics are getting used. Some major exercises advised and a few local applications of analgesic ointments is employed. But no such effective results found.Case: A53 year male patient consulted with complaints of pain and restricted painful movements of left shoulder joint associated with tremor, neck pain and reduced strength in the left-hand Conclusion: Patient was diagnosed as Apabahuk (frozen shoulder) and treated with panchakarma therapies and oral herbal medicines. The encouraging improvement was observed in both subjective and objective parameters.
... 5/10 3/10 2/10 2/10 Placing an object on a high shelf? 9/10 7/10 5/10 3/10 Carrying a heavy object of 10 pounds (4.5 kilograms) 8 ...
Background: Shoulder Osteoarthritis is one of the type of arthritis primarily affecting the elderly as a degenerative and neurological condition with symptoms being pain and disability. As per Ayurveda perspective, it is considered as Sandhigata vata of the shoulder joint. Modern approachcomes with wide range of modalities such as analgesics, muscle relaxants, steroids, physiotherapies, and even operative procedures but none of them gives satisfactory and permanent results to relieve. Materials And Methods: Sandhigata vata of shoulder joint being a vatavyadhi that too occurring Urdhwajatrugata (supra clavicular) region creates a necessity for the modality that can nourish and replenish the vitiated vata and able to improve range of motion with analgesic effect at the desired site, Nasya (Nasal Medication) Karma with a Balya (strengthening) oil wins all the desired conditions hence chosen for the present case. Keeping this in main frame, present case was treated with two sessions of 7 days of Nasya Karma with 7 days of rest period in between along with Trayodashang Guggulu as a palliative drug continued for 21 days. Regular assessments were done with last follow up being on 28 th day. RESULTS: Significant relief was observed and recorded with SPADI (shoulder pain and disability index) score improvement from 71.54% to 26.15%, with improved quality of life. Conclusion: Mahamasha Taila Nasya Karmawith Trayodashang Guggulu canan effective treatment approach for shoulder Osteoarthritis.
... Previous studies revealed that tTrayodashang guggulu is effective in spondylosis (Rathod and Sawant, 2013) and osteoarthritis (Debasis et al., 2015). The different constituents of the trayodashang guggulu formula are reputed in Ayurvedic literature for their shothahara (antiinflammatory) effect. ...
Trayodashang guggulu is an important Ayurvedicpolyherbal formulation containing babula (stem barkof Acacia nilotica), ashwagandha (roots of Withaniasomnifera), hapusa (fruits of Juniperuscommunis), guduchi (stem of Tinosporacordifolia), shatavari (roots of Aspargusrecemosus), gokshuara (fruits of Tribulusterrestris), vradadaru (roots of Argyeria nervosa), rasana (roots and leaves of Pluchealanceolata), satavha (fruits of Anethumsowa), sati (rhizome of Hidichiumspicatum), yavani (Trachyspermumammi fruits), sunthi (rhizome of Zingiberofficinale), shuddhaguggulu (exudates of Commipheramukul) and goghrat (ghee). Trayodashang guggulu is used in the Ayurvedic system of medicine for the treatment of various inflammatory conditions such as arthritis and associated pain. Hence, the present study investigated the in-vitro anti-inflammatory and antioxidant activities of Trayodashang guggulu. Trayodashang guggulu was standardized as per standard procedures and TLC profile was carried as per Ayurvedic Pharmacopoeia of India. In-vitro anti-inflammatory activity of its aqueous extract (AqTG) (in different concentrations) was evaluated by assaying inhibition of albumin denaturation, membrane stabilization (hypotonicity-induced haemolysis), anti-lipoxygenase and antiproteinase activities. The in-vitro antioxidant effect was evaluated by various in-vitro methods viz. DPPH (1, 1-diphenyl-2-picryl-hydrazyl) and hydroxyl radical scavenging and reducing power assay and total phenolic and flavonoids contents. Trayodashang guggulu was confirmed as per pharmacopoeial standards. It showed marked scavenging effect on DPPH and hydroxyl radicals and exhibited strong reducing potential. It also showed inhibition of membrane stabilizing, protein denaturation inhibitory, anti-lipoxygenase and anti-proteinase activities. Trayodashang guggulu exhibited in-vitro anti-inflammatory and antioxidant activities. This preliminary study supports the therapeutic claim of the formulation as an anti-inflammatory drug in the Ayurvedic system of medicine and advocates its use in inflammatory conditions. In view of the in-vitro results, further in-vivo investigations are needed to confirm and strengthen the anti-inflammatory activity of Trayodashang guggulu in pain, inflammation and arthritis.
... The results of this primary analysis are shown in table 2, 3 and figure 1, 2. Always there are complications while using animal subjects for in vivo pharmacological research, like ethical matters and lack of rationale for the use of animals when there are some other methods that can also be used and investigated for the desired results. Hence forth in the current study a bioassay by protein denaturation method was adopted as a part of in vitro estimation of anti-inflammatory property of the formulated Ayurvedic drug 7 . For inflammatory and arthritic conditions, denaturation of tissue proteins is one of the well proved causes. ...
The objective was to assess the in vitro anti inflammatory activity of the ayurvedic formulation Trayodashang Guggulu in comparison to commercially available allopathic drugs. Anti inflammatory activity was estimated by inhibition of protein denaturation method, which in turn was proceeded by adapting two different types of proteins which are egg albumin and bovine serum albumin. These were incubated along with actives and incubated in carefully controlled experimental conditions. The ayurvedic formulation that is prepared prior was compared with six commercially available allopathic standards. The study results showed inhibition of protein according to the concentration of the active used. The ayurvedic formulation showed prominent anti inflammatory activity better than the allopathic drugs at all concentrations that are selected between 200 to 1000µg/ml except when compared to Diclofenac. This study showed that the ayurvedic combination formulation showed good anti inflammatory properties when tested for extent of protein denaturation. But the effect due to each of its constituents should be evaluated further.
... Here in this era driving (car, bike, truck etc.) is the most commonest among people which lead to various Vatavyadhi, it not only occur due to continuous sitting but also driving in uneven road which may lead diseases like Avabahuka (frozen shoulder), Gridhrasi (sciatica), Katigraha (lumbar spondylosis) etc. then who walk more like farmer, militaryman etc leads Vatavyadhi like Sandhivata, then the people who used to stand in some profession like chowkidar, watchman in some mall, some shopkeeper who stand in the whole day, bus conductor etc. increases Vata and leads to Vatavyadhi. Working in front of computer in some service like in bank, computer shopkeeper etc. leads to Vatavyadhi like Grivastambha (cervical spondylosis), 5 Avabahuka (frozen shoulder), sitting also leads to Vatavyadhi like Avabahuka (frozen shoulder) which is found in some businessman which only used to sit whole day which give improper movement of shoulder. Cycling also found the cause of some Vatavyadhi like Sandhivata (osteoarthritis), Katigraha (lumbar spondylosis), frequent journey in bus, train which lead the disease like Grivastambha (cervical spondylosis), Katigraha (lumbar spondylosis), Gridhasi (sciatica) etc. which are found in engineer, some MBA, some serviceman which have to travel in bus/train up to office etc. ...
Vata vy a dhi get the prime importance in A yurvedic classic, though it was prevalent in ancient time but these days this is increa sing with rising of technology. People used to go towards urbanization, utilized technology which instead of making life c omfortable develops a busy life and people are away from maintain ing the Dinacharya R ituch ary, S advrita et c. which increases the rate of Vatavyadhi . The causes of Vatavyadi which are described in Ayurvedic text are different according to mod e rn era due changing life styl e though sign and symptoms of different diseases are same, so an analysis is important to make correlation between the causes of ancient era and modern era. A survey study was done on 500 patients of Vatavyadhi , in National institute of Ayurveda, Jaipur, India, in some yoga Kendra in Jaipur, India on the base of duly formed proforma. The causes of Vata vyadhi which we re giv en in different texts of A yurveda were compiled; make questionnaire as per this modern era and proforma was made on the basis of this. Though there are different causes but the commonest causes of this era which develops Vatavyadhi was more highlighted in this survey.
The present study was undertaken to evaluate the Maximum Tolerated Dose and No Observed Adverse Effect Level of Trayodashang guggulu (TG), an Ayurvedic classical formulation, in Wistar rats. TG was administered orally to Wistar rats in as single dose (2000 mg/kg body weight) in an acute toxicity study. Ninety days repeated dose oral toxicity (subchronic) study was carried out by using three dose levels (250, 500 and 1000 mg/kg body weight) administered orally daily for 90 consecutive days and derived from 28 days dose range-finding study. In acute and subchronic toxicity studies, animals were observed for general clinical signs, mortality, weekly body weight changes, weekly feed intake, weekly water intake, blood biochemical investigation, haematological parameters, and gross pathological and histological investigations. In an acute toxicity study, the dose level of 2000 mg/kg of TG was found to be safe when given at a single dose. In the dose rangefinding study and subchronic toxicity study TG was found to be safe at all tested dose levels. No significant changes in food and water consumption, haematological and blood biochemical parameters were noticed at any dose level in both studies. No major changes were noticed during histopathological evaluation in ninety days repeated dose oral toxicity study. The study concluded that the Maximum Tolerated Dose of TG was found at 2000 mg/kg body weight and the No Observed Adverse Effect Level was found at 1000 mg/kg in Wistar rats.