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Gastrointestinal stromal tumor is a rare pathology. GISTs account for 0.3-1% of all tumors of the gastrointestinal tract. At the same time, this type of cancer is the most common, malignant, non-epithelial tumor of the gastrointestinal tube. Over 90% of GISTs are found in the stomach and small intestine. This cancer usually develops without charact...
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The association of a
gastrointestinal stromal tumor (GIST) with an epithelial tumor of the digestive
tract is very rare and frequently discovered by chance during the surgical
treatment of digestive carcinoma. These tumors developed from the mesenchyme are
known to have a good prognosis given their low malignancy potential. The
possibility of a gen...
- [...]
Background and study aims Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal tract. Up to the present time, complete surgical excision has been the standard treatment for primary GISTs greater than 2 cm. It is well known that tumor rupture during surgery is an independent risk factor for peritonea...
Les Tumeurs Stromales Gastro-intestinales « GIST » sont une forme très rare de cancers du tube digestif appartenant à la famille des sarcomes. Le but de ce travail est d'établir le profil épidémiologique et évolutif ainsi que les difficultés diagnostique et thérapeutique de cette pathologie maligne prise en charge dans un pays en développement. Une...
Citations
... The recent advances in tissue evaluation and molecular analysis have earned a deeper understanding of GIST lesion, which was considered as a disease arising from neurogenic or smooth muscle [1]. Histologically, GIST is resulted from an anomaly transformation in the interstitial Cajal cells, responsible for motor function of the GI tract [2]. Around 80% of GISTs harbor KIT gene mutations, which would result in abnormally activation of the KIT receptor that further leads to tumor growth. ...
Background
Gastrointestinal stromal tumor (GIST) can arise anyplace along the gastrointestinal (GI) tract. The uncommon tumor location in groin area is rarely reported.
Case presentation
We herein reported a metastasized case presented as GI hemorrhage complicated with indirect hernia, and underwent tumor cytoreduction, herniorrhaphy and chemotherapy for jejunal GIST. The case was described consecutively based on the process of surgical management, with a good follow-up result. A literature review by searching similar case reports from two national medical databases was performed to summarize clinical features of such unusual presentation of GIST, which included hernia characteristics, short- and long-term outcomes of this disease. It showed GIST presenting as groin hernia was rarely reported and all available 11 cases suggested a primary tumor and required both tumor resection and hernia repair. The long-term results indicated 64.3% overall survival at 5 years after the incidental diagnosis.
Conclusions
Inguinal hernia is an extremely rare presentation of GIST, with limited case reports available in the literature. A radical involving tumor resection plus hernia repair is an optimal surgical approach for such uncommon condition. An adjuvant medication mounting on mutated KIT gene should be strictly followed for high risk cases.
... Only 5% of the GISTs have been found in the colon and less than 5% in the esophagus. In some cases, the primary site of the stromal tumor is on the outside of the gastrointestinal tract and behind the peritoneum which is described for less than 10% of the diagnosed cases [6]. ...
Gastrointestinal Stromal Tumor is considered as one of the rare tumors in the gastrointestinal tract and is mainly found in the gastrointestinal lining and the interstitial cells of Cajal, more than half of which arise in the stomach and the rest do in the small intestine and along the gastrointestinal tract. Nowadays, the major role of micro-RNAs is known for any researcher. Our studies show that micro-RNAs, which play an interfering role in the molecular processes, can have significant destructive or very efficient and beneficial impact on all the stages from inception to final treatment. This overview article deals with the various micro-RNAs impacting on this tumor from different aspects and finally offers the best mi-RNA in terms of its properties.
... Gastrointestinal stromal tumor (GIST) is a mesenchymal tumor originating from Cajal cells responsible for the motility of the gastrointestinal tract (1). GISTs are most commonly located in stomach (60-70%), small intestines (20-30%), colon and rectum (5%) (2), but it may be localized anywhere from esophagus to anus. ...
Gastrointestinal stromal tumors, are most common sarcoma of the gastrointestinal tract, originate from Cajal cells which are responsible for the motility of the gastrointestinal tract. This sarcoma is most commonly observed in stomach and small intestines, can rarely be located in omentum, mesentery or retroperitoneum. Herein, we aimed to present a case of gastrointestinal stromal tumor presented as incarcerated inguinal hernia.
Key words: Gastrointestinal stromal tumor, GIST, hernia, inguinal hernia, incarceration
... Gastrointestinal stromal tumor (GIST) is a mesenchymal tumor originating from Cajal cells responsible for the motility of the gastrointestinal tract (1). GISTs are most commonly located in stomach (60-70%), small intestines (20-30%), colon and rectum (5%) (2), but it may be localized anywhere from esophagus to anus. ...
Objective: Gastrointestinal stromal tumors, are most common sarcoma of the gastrointestinal tract, originate from Cajal cells which are responsible for the motility of the gastrointestinal tract. This sarcoma is most commonly observed in the stomach and small intestines can rarely be located in the omentum, mesentery or retroperitoneum. Case: Herein, we aimed to present a case of gastrointestinal stromal tumor presented as incarcerated inguinal hernia
